ArticleAmerican journal of translational research2018
Systematic analysis of lncRNAs, mRNAs, circRNAs and miRNAs in patients with postmenopausal osteoporosis.
Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis.PloS one · 2022Pooled it
- Differentially expressed circulating miRNAs in postmenopausal osteoporosis: a meta-analysis.Bioscience reports · 2019Pooled it
- The Value Analysis of Hsa_circ_0086004 and Hsa-miR-665 in the Diagnosis of Fractures and Promotion of Fracture Healing in Osteoporosis Patients.Biochemical genetics · 2026Article
- LncRNA-Gm5532 deficiency alleviates bone resorption by inhibiting mitochondrial respiration through iASPP/NRF2.Cell biology and toxicology · 2026Article
- Elevated cytokines in osteoporotic blood correlate with immune microenvironment shifts and dysregulated circRNA profiles.Frontiers in immunology · 2026Article
- Krüppel-like factors family in health and disease.MedComm · 2024Review
- lncTIMP3 promotes osteogenic differentiation of bone marrow mesenchymal stem cells via miR-214/Smad4 axis to relieve postmenopausal osteoporosis.Molecular biology reports · 2024Article
- Noncoding RNAs in skeletal development and disorders.Biological research · 2024Review
- Identification of the transcriptome signatures and immune-inflammatory responses in postmenopausal osteoporosis.Heliyon · 2024Article
- Role of miRNA-regulated type H vessel formation in osteoporosis.Frontiers in endocrinology · 2024Review
- IMPC-based screening revealed thatFrontiers in cell and developmental biology · 2024Article
- Common miRNAs of Osteoporosis and Fibromyalgia: A Review.International journal of molecular sciences · 2023Review
- Construction of ceRNA regulatory networks for osteoporosis.Molecular medicine reports · 2023Article
- miR-10a-3p Participates in Nacre Formation in the Pearl Oyster Pinctada fucata martensii by Targeting NPY.Marine biotechnology (New York, N.Y.) · 2023Article
- The role of noncoding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells.Non-coding RNA research · 2023Review
- Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases.Frontiers in pharmacology · 2023Review
- Comprehensive analysis of epigenetics mechanisms in osteoporosis.Frontiers in genetics · 2023Review
- Circular RNAs: typical biomarkers for bone-related diseases.Journal of Zhejiang University. Science. B · 2022Article
- Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1.Cancer cell international · 2022Article
- LncRNA TUG regulates osteogenic differentiation of bone marrow mesenchymal stem cells via miRNA-204/SIRT 1.Journal of musculoskeletal & neuronal interactions · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis (OP) is a disease characterized by bone loss, imbalance of bone metabolism and destruction of trabecular microstructure, and associated with menopause. Studies have shown that immune related lymphocytes are involved in bone metabolism. However, the molecular mechanisms hidden in the interaction of lymphocytes with OP need to be further studied. In the present study, we investigated the expression profiles and differences of lncRNAs, mRNAs, circRNAs and miRNAs in peripheral blood lymphocytes of patients with postmenopausal OP using Illumina-based complementary DNA (cDNA) deep sequencing (RNA-seq). 70 lncRNAs, 475 mRNAs, 260 circRNAs and 13 miRNAs were differentially expressed in patients with postmenopausal osteoporosis (OP group) compared with healthy controls (NC group). The functions of differentially expressed lncRNAs, circRNA, miRNA and potential targeting genes were predicted by Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Complex lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA regulatory networks were constructed based on differentially expressed RNAs. Taken together, our study indicated that lncRNAs, mRNA, circRNAs and miRNA could associate with the occurrence of postmenopausal OP and may be as possible biomarkers and target genes in lymphocytes for OP.
Indexed as
Identifiers
29887963PMC5992556W2808223449What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.