Evidence map›Paper›PMID 29887952›Full record

ArticleAmerican journal of translational research2018

Identification of the tumor-suppressive function of circular RNA ITCH in glioma cells through sponging miR-214 and promoting linear ITCH expression.

Feng Li, Ke Ma, Meihua Sun, Shan Shi

RetractedOpen access · greenAbstract readRetracted Publication
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  9. Emerging roles of circular RNAs in osteoporosis.Journal of cellular and molecular medicine · 2021
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  19. Review on circular RNAs and new insights into their roles in cancer.Computational and structural biotechnology journal · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Feng LiDepartment of Pediatric Outpatient, The First Hospital of Jilin University Changchun 130021, Jilin Province, China.
Ke MaDepartment of Pediatric Outpatient, The First Hospital of Jilin University Changchun 130021, Jilin Province, China.
Meihua SunDepartment of Pediatric Outpatient, The First Hospital of Jilin University Changchun 130021, Jilin Province, China.
Shan ShiDepartment of Pediatric Outpatient, The First Hospital of Jilin University Changchun 130021, Jilin Province, China.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) is a class of endogenous noncoding RNAs that, unlike linear RNAs, form covalently closed continuous loops and have recently shown huge capabilities as gene regulators in mammals. However, little is known about their roles in cancer initiation and progression, such as glioma. In this study, we determined the expression level of circRNA ITCH (cir-ITCH) in glioma specimens and further investigated its functional role in glioma cells. By performing Taq-man based RT-qPCR, we identified that cir-ITCH was downregulated in glioma tissues and cell lines. Receiver operating curve analysis suggested cir-ITCH showed a relatively high diagnostic accuracy. Kaplan-Meier assay revealed that decreased cir-ITCH level was associated with poor survival of glioma patients. The functional relevance of cir-ITCH was further examined by biological assays. Cir-ITCH significantly promoted the capacities of cell proliferation, migration and invasion of glioma cells. The linear isomer of cir-ITCH, ITCH gene was then identified as the down stream target. Subsequently, RNA immunoprecipitation clearly showed that cir-ITCH sponged miR-214, which further promoted the ITCH expression. Finally, the gain and loss functional assays indicate that cir-ITCH plays an anti-oncogenic role through sponging miR-214 and regulating ITCH-Wnt/β-catenin pathway. These results suggest that cir-ITCH is a tumor-suppressor gene in glioma and may serve as a promising prognostic biomarker for glioma patients. Therefore, restoration of cir-ITCH expression could be a future direction to develop a novel treatment strategy.

Indexed as

Cir-ITCHgliomalinear ITCHmiR-214Wnt/β-catenin pathway

Identifiers

PMID29887952
PMCPMC5992557
OpenAlexW2982677707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.