ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2018
Comparison of salivary testosterone levels in different phases of bipolar I disorder and control group.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Salivary hormones in depression: the future in diagnosis and treatment.Annals of general psychiatry · 2025Review
- Peripheral biomarkers to differentiate bipolar depression from major depressive disorder: a real-world retrospective study.BMC psychiatry · 2024Article
- Hormonal and inflammatory signatures of different mood episodes in bipolar disorder: a large-scale clinical study.BMC psychiatry · 2023Article
- An Exploratory Cohort Study of the Association between the Level of Testosterone and Suicidal Ideation in Hospitalized Adolescent Females with Depression in China.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Gene expression pattern ofJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTestosterone is considered as a primary sex hormone, also known as an important anabolic steroid, that may involve in various mental disorders such as bipolar I disorder (BID). The goal of this study was to compare the testosterone salivary levels between different phases of BID and its association with the clinical features of BID. MATERIALS AND
methodsIn a case-control study, 15 patients in the mania phase, 10 patients in the depression phase, and 16 in the euthymia phase were selected as patient groups. 18 healthy sex- and age-matched individuals were considered as healthy control group. Salivary samples obtained from all patients and control group and levels of testosterone were determined in saliva using an enzyme-linked immunosorbent assay. All statistical calculations were conducted with the software Statistical Package for Social Science version 20 (IBM Inc., Chicago, IL, USA).
resultsThe mean testosterone level in euthymia phase was 186.34 ± 182.62 pg/mL, mania phase was 239.29 ± 273.22 pg/mL, depression was 153.49 ± 222.50 pg/mL, and healthy participants was 155.73 ± 126.0 pg/mL; no significant difference was found between groups (
conclusionOur findings do not reveal significant difference between different phases of BID in terms of salivary testosterone levels. However, more comprehensive studies with larger sample size are required to confirm our findings.
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