ReviewNeural plasticity2018
A Proposed Molecular Mechanism for Physical Analgesia in Chronic Pain.
Review in Neural plasticity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Adhesive pyramidal thorn patches provide pain relief to athletes.The Kaohsiung journal of medical sciences · 2019Trial
- Near-infrared spectroscopic study of blood flow changes in the dorsolateral prefrontal cortex during pain relief by odor stimulation.Biophysics and physicobiology · 2025Article
- Revisiting oxytocin generation in keratinocytes.Biophysics and physicobiology · 2023Article
- Profile of dorsal root ganglion neurons: study of oxytocin expression.Molecular brain · 2022Article
- Dorsolateral prefrontal cortex sensing analgesia.Biophysics and physicobiology · 2022Article
- Influence of gap junctions upon CaBiophysics and physicobiology · 2022Article
- Peripheral-neuron-like properties of differentiated human dental pulp stem cells (hDPSCs).PloS one · 2021Article
- Activation of the orbitofrontal cortex by both meditation and exercise: A near-infrared spectroscopy study.PloS one · 2021Article
- Pain relief associated with decreased oxyhemoglobin level in left dorsolateral prefrontal cortex.PloS one · 2021Article
- A novel role of oxytocin: Oxytocin-induced well-being in humans.Biophysics and physicobiology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although pain is indispensable for survival, chronic pain places a heavy burden on humans. As the efficacy of opioid treatment is limited, the development of alternative methods of pain relief without medication is desirable. Recently, we have developed a novel method of physical analgesia using an adhesive "pyramidal thorn patch." When we apply about 3 trials of these patches on the skin of a pain region, the pain region moves toward the spinal cord like a "cutaneous rabbit," and finally, the pain vanishes. In the present review, we propose a molecular mechanism for this analgesic method or pain relief following application of the pyramidal thorn patch where firstly the mechanoreceptors and their related nerves under the skin are activated in response to touch. Transient receptor potential (TRP) channels serve as mechanosensitive channels within these mechanoreceptors. We further propose that activation of the nerves connected with the mechanoreceptors releases oxytocin, which has an antinociceptive function and activates TRP channels to hyperpolarize the pain signal nerves. We believe that our system will pave the way for alternative pain treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.