Evidence map›Paper›PMID 29887843›Full record

ArticleFrontiers in microbiology2018

Benchmark Evaluation of True Single Molecular Sequencing to Determine Cystic Fibrosis Airway Microbiome Diversity.

Andrea Hahn, Matthew L Bendall, Keylie M Gibson, Hollis Chaney, Iman Sami, Geovanny F Perez, Anastassios C Koumbourlis, Timothy A McCaffrey, Robert J Freishtat, Keith A Crandall

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Andrea HahnDivision of Infectious Diseases, Children's National Health System, Washington, DC, United States.
Matthew L BendallComputational Biology Institute, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States.
Keylie M GibsonComputational Biology Institute, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States.
Hollis ChaneyDepartment of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Iman SamiDepartment of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Geovanny F PerezDepartment of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Anastassios C KoumbourlisDepartment of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Timothy A McCaffreyDivision of Genomic Medicine, The George Washington University, Washington, DC, United States.
Robert J FreishtatDepartment of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Keith A CrandallComputational Biology Institute, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States.
George Washington University · USChildren's National · USMilken Institute · US

Funding

Clinical and Translational Science Institute at Children's NationalUL1TR000075 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2012 to 2015
$13.7M
K12 Career Development Program: Omics of Pediatric Lung Diseases in DCK12HL119994 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI FREISHTAT, ROBERT J · 2013 to 2017
$1.3M
NCATS NIH HHS UL1 TR000075NHLBI NIH HHS K12 HL119994
6 · The paper itself

Abstract

Cystic fibrosis (CF) is an autosomal recessive disease associated with recurrent lung infections that can lead to morbidity and mortality. The impact of antibiotics for treatment of acute pulmonary exacerbations on the CF airway microbiome remains unclear with prior studies giving conflicting results and being limited by their use of 16S ribosomal RNA sequencing. Our primary objective was to validate the use of true single molecular sequencing (tSMS) and PathoScope in the analysis of the CF airway microbiome. Three control samples were created with differing amounts of

Indexed as

antibioticscystic fibrosismetagenomicsmicrobiometrue single molecule DNA sequencing

Identifiers

PMID29887843
PMCPMC5980964
OpenAlexW2801768664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.