Evidence map›Paper›PMID 29887828›Full record

ArticleFrontiers in neurology2018

Mild Traumatic Brain Injury in Adolescent Mice Alters Skull Bone Properties to Influence a Subsequent Brain Impact at Adulthood: A Pilot Study.

Thomas J McColl, Rhys D Brady, Sandy R Shultz, Lauren Lovick, Kyria M Webster, Mujun Sun, Stuart J McDonald, Terence J O'Brien, Bridgette D Semple

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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  10. Mechanosensation in traumatic brain injury.Neurobiology of disease · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Thomas J McCollDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Rhys D BradyDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Sandy R ShultzDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Lauren LovickDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Kyria M WebsterDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Mujun SunDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Stuart J McDonaldDepartment of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC, Australia.
Terence J O'BrienDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Bridgette D SempleDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
The Royal Melbourne Hospital · AUMonash University · AULa Trobe University · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mild traumatic brain injuries (mTBI) are common during adolescence, and limited clinical evidence suggests that a younger age at first exposure to a mTBI may lead to worse long-term outcomes. In this study, we hypothesized that a mTBI during adolescence would predispose toward poorer neurobehavioral and neuropathological outcomes after a subsequent injury at adulthood. Mice received a mild weight drop injury (mTBI) at adolescence (postnatal day 35; P35) and/or at adulthood (P70). Mice were randomized to 6 groups:

Indexed as

behaviorboneinflammationmild traumatic brain injurymouse model

Identifiers

PMID29887828
PMCPMC5980957
OpenAlexW2800785616

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.