Evidence map›Paper›PMID 29887525›Full record

ArticleThe Journal of biological chemistry2018

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a

Nadine D Younan, Ko-Fan Chen, Ruth-Sarah Rose, Damian C Crowther, John H Viles

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Circadian rhythms in neurodegenerative disorders.Nature reviews. Neurology · 2022
    Review
  13. Article
  14. Article
  15. Tau Exon 10 Inclusion by PrPInternational journal of molecular sciences · 2021
    Article
  16. Review
  17. Evidence for aggregation-independent, PrPProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  18. Article
  19. The Toxicity and Polymorphism of β-Amyloid Oligomers.International journal of molecular sciences · 2020
    Review
  20. Genetic Dissection of Alzheimer's Disease UsingInternational journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Nadine D YounanFrom the School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom.
Ko-Fan Chenthe Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom, and.
Ruth-Sarah RoseFrom the School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom.
Damian C Crowtherthe Neuroscience IMED Biotech Unit, AstraZeneca, Cambridge CB21 6GH, United Kingdom damian.crowther@azneuro.com.ORCID 0000-0001-7791-1396
John H VilesFrom the School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom, j.viles@qmul.ac.uk.
Queen Mary University of London · GBAstraZeneca (United Kingdom) · GBUniversity College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/D005027/1Biotechnology and Biological Sciences Research Council BB/M023877/1Medical Research Council G0700990Wellcome TrustWellcome Trust 093241/Z/10/Z
6 · The paper itself

Abstract

The cellular prion protein (PrP

Indexed as

Alzheimer DiseaseAmyloidAmyloid beta-PeptidesAnimalsCircadian RhythmDisease Models, AnimalDrosophila melanogasterLongevityMesocricetusNeurotoxicity SyndromesPrion ProteinsProtein BindingProtein MultimerizationAmyloidAmyloid beta-PeptidesPrion ProteinsAlzheimer's diseaseamyloid-beta (AB)animal modelcircadian rhythmDrosophilafibrilneurodegenerative diseaseoligomerprionprotein misfolding

Identifiers

PMID29887525
PMCPMC6109938
OpenAlexW2806497463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.