Evidence map›Paper›PMID 29887523›Full record

ArticleThe Journal of biological chemistry2018

Insight into the evolution of nidovirus endoribonuclease based on the finding that nsp15 from porcine

Anjun Zheng, Yuejun Shi, Zhou Shen, Gang Wang, Jiale Shi, Qiqi Xiong, Liurong Fang, Shaobo Xiao, Zhen F Fu, Guiqing Peng

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  6. Review
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  9. Review
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  11. Article
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  14. Article
  15. Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15.bioRxiv : the preprint server for biology · 2020
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Anjun ZhengState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Yuejun ShiState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China; College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Zhou ShenState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Gang WangState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Jiale ShiState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Qiqi XiongCollege of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Liurong FangState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Shaobo XiaoState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Zhen F FuDepartment of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602.
Guiqing PengState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China. Electronic address: penggq@mail.hzau.edu.cn.
State Key Laboratory of Agricultural MicrobiologyCenter of Hubei Cooperative Innovation for Emissions Trading System · CNHuazhong Agricultural University · CNUniversity of Georgia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nidovirus endoribonucleases (NendoUs) include nonstructural protein 15 (nsp15) from coronaviruses and nsp11 from arteriviruses, both of which have been reported to participate in the viral replication process and in the evasion of the host immune system. Results from a previous study of coronaviruses SARS-CoV, HCoV-229E, and MHV nsp15 indicate that it mainly forms a functional hexamer, whereas nsp11 from the arterivirus PRRSV is a dimer. Here, we found that porcine

Indexed as

Amino Acid SequenceArterivirusBinding SitesCloning, MolecularCoronavirusCrystallography, X-RayEndoribonucleasesEscherichia coliEvolution, MolecularGene ExpressionGenetic VectorsModels, MolecularNidoviralesProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandEndoribonucleasesnidoviral uridylate-specific endoribonucleaseProtein SubunitsRecombinant ProteinsViral Nonstructural ProteinsendoribonucleaseevolutionnidovirusoligomerizationPDCoV nsp15protein evolutionprotein purificationviral protein

Identifiers

PMID29887523
PMCPMC6078464
OpenAlexW2806609010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.