Observational studyInternational journal of cardiology2018
New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study.
Observational study in International journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Definitions and outcomes reported in studies investigating the management of new onset atrial fibrillation in acutely unwell patients admitted to the intensive care unit: a scoping review.European heart journal open · 2026Review
- Clinical Profiles of Hospitalized Middle Eastern Patients With Nonvalvular Atrial Fibrillation: Analysis From the JoFib Study.International journal of vascular medicine · 2026Article
- Usefulness of Blood-Urea-Nitrogen to Serum Albumin Ratio for In-hospital Mortality Predictions in Atrial Fibrillation Patients Admitted to the Intensive Care Unit: A Retrospective Analysis From MIMIC-IV Database.Reviews in cardiovascular medicine · 2025Article
- Atrial fibrillation in critical illness: state of the art.Intensive care medicine · 2025Review
- Prevalence, Risk Factors, and Mortality of New-Onset Atrial Fibrillation in Mechanically Ventilated Critically Ill Patients.Journal of clinical medicine · 2024Article
- An International Survey of the Management of Atrial Fibrillation in Critically Unwell Patients.Critical care explorations · 2024Article
- Usefulness of lactate to albumin ratio for predicting in-hospital mortality in atrial fibrillation patients admitted to the intensive care unit: a retrospective analysis from MIMIC-IV database.BMC anesthesiology · 2024Article
- Article
- Article
- Impact of New-Onset Atrial Fibrillation on Mortality in Critically Ill Patients.Clinical epidemiology · 2024Article
- Association between aspirin and mortality in critically ill patients with atrial fibrillation: a retrospective cohort study based on mimic-IV database.Frontiers in cardiovascular medicine · 2024Article
- Unveiling the silent threat of new onset atrial fibrillation in covid-19 hospitalized patients: A retrospective cohort study.PloS one · 2024Article
- New-Onset Atrial Fibrillation in the Critically Ill COVID-19 Patients Hospitalized in the Intensive Care Unit.Journal of clinical medicine · 2023Review
- Arrhythmias in Critically Ill Surgical and Non-surgical Patients: A National Propensity-Matched Study.World journal of surgery · 2023Article
- Identification of novel variants for complicating cardiac disease in the scrub typhus infection using whole genome sequencing.The Korean journal of internal medicine · 2023Article
- Association of Dexmedetomidine With New-Onset Atrial Fibrillation in Patients With Critical Illness.JAMA network open · 2023Article
- Atrial Fibrillation and Sepsis in Elderly Patients and Their Associaton with In-Hospital Mortality.Arquivos brasileiros de cardiologia · 2023Review
- Risk factors for new-onset atrial fibrillation during critical illness: A Delphi study.Journal of the Intensive Care Society · 2022Article
- Analysis of the association between atrial fibrillation with in-hospital mortality in people admitted for community-acquired pneumonia through an observational, nation-wide, sex-stratified study.Scientific reports · 2022Observational
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Authors and funding
14 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial fibrillation (AFib) is associated with adverse outcome in critical illness, but whether this effect is independent from other risk factors remains uncertain. New-onset AFib during critical illness may be independently associated with increased in-hospital and long-term risk of death.
methodsFROG-ICU was a prospective, observational, multi-centre cohort study designed to investigate the outcome of critically ill patients. Inclusion criteria were invasive mechanical ventilation and/or treatment with a positive inotropic agent for >24 h. Heart rhythm was assessed at inclusion and during ICU stay with digital ECG recordings. Among patients who had AFib during ICU stay, new-onset and recurrent AFib were diagnosed in patients without and with previous history of AFib, respectively. Primary endpoint was in-hospital mortality; secondary endpoint was 1-year mortality among ICU survivors.
resultsThe study included 1841 critically ill patients. During ICU stay, AFib occurred in 343 patients (19%). New-onset AFib (n = 212) had higher in-hospital mortality compared to no AFib (47 vs. 23%, P < 0.001) or recurrent AFib (34%, P = 0.032). New-onset AFib showed increased risk of in-hospital death after multivariable adjustment compared to no AFib (OR 1.6, P = 0.003) or recurrent AFib (OR 1.8, P = 0.02). Among the 1464 ICU-survivors, new-onset AFib during ICU stay showed higher post-ICU risk of death compared to no AFib (HR 2.2, P < 0.001). After multivariable adjustment, new-onset AFib showed higher post-ICU risk of death compared to no AFib (HR 1.6, P = 0.03).
conclusionNew-onset AFib is independently associated with in-hospital and post-ICU risk of death in critically ill patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.