ArticleAcademic radiology2019
Breast Cyst Fluid Analysis Correlations with Speed of Sound Using Transmission Ultrasound.
Article in Academic radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
- A multimodal ultrasound approach: quantitative speed-of-sound, elastography, and B-mode imaging for predicting papillary thyroid carcinoma invasiveness.Quantitative imaging in medicine and surgery · 2026Article
- Evaluation of the clinical efficacy of mammotome minimally invasive rotary cutting surgery in the treatment of benign breast tumors: a comparative study.Journal of robotic surgery · 2025Article
- Acoustomotive diffuse correlation spectroscopy for sensing mechanical stiffness in tissue-mimicking phantoms.Biomedical optics express · 2024Article
- Breast Tomographic Ultrasound: The Spectrum from Current Dense Breast Cancer Screenings to Future Theranostic Treatments.Tomography (Ann Arbor, Mich.) · 2024Review
- Iterative Pulse-Echo Tomography for Ultrasonic Image Correction.Sensors (Basel, Switzerland) · 2024Article
- Value of inversion imaging to diagnosis in differentiating malignant from benign breast masses.BMC medical imaging · 2023Article
- Low frequency 3D transmission ultrasound tomography: technical details and clinical implications.Zeitschrift fur medizinische Physik · 2023Article
- Clinical Importance of 3D Volography in Breast Imaging.Advances in experimental medicine and biology · 2023Article
- Coherence Metrics for Reader-Independent Differentiation of Cystic From Solid Breast Masses in Ultrasound Images.Ultrasound in medicine & biology · 2023Article
- The Potential Role of the Fat-Glandular Interface (FGI) in Breast Carcinogenesis: Results from an Ultrasound Tomography (UST) Study.Journal of clinical medicine · 2021Article
- Multicenter Study of Whole Breast Stiffness Imaging by Ultrasound Tomography (SoftVue) for Characterization of Breast Tissues and Masses.Journal of clinical medicine · 2021Article
- Speed-of-sound imaging using diverging waves.International journal of computer assisted radiology and surgery · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
RATIONALE AND
objectivesThe purpose of this work is to determine if the speed of sound value of a breast cyst can aid in the clinical management of breast masses. Breast macrocysts are defined as fluid-filled tissue masses >1 cm in diameter and are thought to be aberrations of normal development and involution, often associated with apocrine metaplasia. The benign natural history of breast cysts is well known, and it is important to obtain high specificity in breast imaging to avoid unnecessary biopsies in women who have benign diseases, particularly those with dense breast tissue. Transmission ultrasound is a tomographic imaging modality that generates high-resolution, 3D speed of sound maps that could be used to identify breast tissue types and act as a biomarker to differentiate lesions. We performed this study to investigate the microanatomy of macrocysts observed using transmission ultrasound, as well as assess the relationship of speed of sound to the physical and biochemical parameters of cyst fluids. MATERIALS AND
methodsCyst fluid samples were obtained from 37 patients as part of a case-collection study for ultrasound imaging of the breast. The speed of sound of each sample was measured using a quantitative transmission ultrasound scanner in vivo. Electrolytes, protein, cholesterol, viscosity, and specific gravity were also measured (in the aspirated cyst fluid) to assess their relationship to the speed of sound values obtained during breast imaging.
resultsWe found positive correlations between viscosity and cholesterol (r = 0.71) and viscosity and total protein × cholesterol (r = 0.78). Additionally, we performed direct cell counts on cyst fluids and confirmed a positive correlation of number of cells with speed of sound (r = 0.74). The speed of sound of breast macrocysts, as observed using transmission ultrasound, correlated with the cytological features of intracystic cell clumps.
conclusionOn the basis of our work with speed as a classifier, we propose a spectrum of breast macrocysts from fluid-filled to highly cellular. Our results suggest high-speed cysts are mature macrocysts with high cell counts and many cellular clumps that correlate with cyst microanatomy as seen by transmission ultrasound. Further studies are needed to confirm our findings and to assess the clinical value of speed of sound measurements in breast imaging using transmission ultrasound.
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