Evidence map›Paper›PMID 29887305›Full record

ArticleCurrent biology : CB2018

Distinct Circuits for Recovery of Eye Dominance and Acuity in Murine Amblyopia.

Céleste-Élise Stephany, Xiaokuang Ma, Hilary M Dorton, Jie Wu, Alexander M Solomon, Michael G Frantz, Shenfeng Qiu, Aaron W McGee

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  12. Cre driver mouse lines for thalamocortical circuit mapping.The Journal of comparative neurology · 2022
    Article
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  16. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Céleste-Élise StephanyDevelopmental Neuroscience Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Xiaokuang MaDepartment of Basic Medical Sciences, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA; Department of Physiology, Shantou University Medical College, Shantou, 515041 Guangdong, China.
Hilary M DortonDevelopmental Neuroscience Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Jie WuDepartment of Physiology, Shantou University Medical College, Shantou, 515041 Guangdong, China; Departments of Neurology and Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA; Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40202, USA.
Alexander M SolomonDevelopmental Neuroscience Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Michael G FrantzDevelopmental Neuroscience Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Shenfeng QiuDepartment of Basic Medical Sciences, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA; Department of Physiology, Shantou University Medical College, Shantou, 515041 Guangdong, China. Electronic address: sqiu@email.arizona.edu.
Aaron W McGeeDevelopmental Neuroscience Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA; Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40202, USA. Electronic address: aaron.mcgee@louisville.edu.
Children's Hospital of Los Angeles · USUniversity of Southern California · USBarrow Neurological Institute · USShantou University · CNShantou University Medical College · CNUniversity of Louisville · US

Funding

Deciphering Inhibition of Visual Plasticity by NgR1R01EY021580 · NEI · UNIVERSITY OF LOUISVILLE · PI MCGEE, AARON W · 2012 to 2020
$3.1M
Disinhibition and experience-dependent visual plasticityR01EY027407 · NEI · UNIVERSITY OF LOUISVILLE · PI MCGEE, AARON W, TRACHTENBERG, JOSHUA · 2017 to 2020
$1.9M
Met Signaling in Neural Development and Circuitry FormationR00MH087628 · NIMH · UNIVERSITY OF ARIZONA · PI QIU, SHENFENG · 2012 to 2014
$718k
NEI NIH HHS R01 EY021580NEI NIH HHS R01 EY027407NIMH NIH HHS R00 MH087628
6 · The paper itself

Abstract

Degrading vision by one eye during a developmental critical period yields enduring deficits in both eye dominance and visual acuity. A predominant model is that "reactivating" ocular dominance (OD) plasticity after the critical period is required to improve acuity in amblyopic adults. However, here we demonstrate that plasticity of eye dominance and acuity are independent and restricted by the nogo-66 receptor (ngr1) in distinct neuronal populations. Ngr1 mutant mice display greater excitatory synaptic input onto both inhibitory and excitatory neurons with restoration of normal vision. Deleting ngr1 in excitatory cortical neurons permits recovery of eye dominance but not acuity. Reciprocally, deleting ngr1 in thalamus is insufficient to rectify eye dominance but yields improvement of acuity to normal. Abolishing ngr1 expression in adult mice also promotes recovery of acuity. Together, these findings challenge the notion that mechanisms for OD plasticity contribute to the alterations in circuitry that restore acuity in amblyopia.

Indexed as

AmblyopiaAnimalsDominance, OcularFemaleMaleMiceNeuronsNogo Receptor 1Visual AcuityNogo Receptor 1Rtn4r protein, mouseamblyopiaeye dominanceleucine-rich repeatplasticityvisual acuity

Identifiers

PMID29887305
PMCPMC6008222
OpenAlexW2806568135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.