Evidence map›Paper›PMID 29887265›Full record

ArticleCell chemical biology2018

Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled Peptide.

Sterling R Payne, Daniel I Pau, Amanda L Whiting, Ye Joon Kim, Blaze M Pharoah, Christina Moi, Christopher N Boddy, Federico Bernal

Open access · bronzeAbstract read
In one paragraph

Article in Cell chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Potentiation of Aminoglycoside Lethality by CAntimicrobial agents and chemotherapy · 2019
    Article
  9. Article
  10. Sub-inhibitory Effects of Antimicrobial Peptides.Frontiers in microbiology · 2019
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sterling R PayneLaboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Daniel I PauDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Amanda L WhitingLaboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Ye Joon KimLaboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Blaze M PharoahLaboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Christina MoiDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Christopher N BoddyDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Federico BernalLaboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: bernalf@mail.nih.gov.
National Cancer Institute · USUniversity of Ottawa · CA

Funding

Chemical Targeting of Multi-Protein ComplexesZIABC011511 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BERNAL, FEDERICO · 2013 to 2019
$1.4M
Targeting protein-DNA interactions in prokaryotic systemsZIABC011655 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BERNAL, FEDERICO · 2015 to 2019
$1.3M
Intramural NIH HHS ZIA BC011655
6 · The paper itself

Abstract

In response to environmental and other stresses, the σ

Indexed as

Anti-Bacterial AgentsDrug DesignGene Expression Regulation, BacterialGenes, BacterialGram-Negative BacteriaGram-Negative Bacterial InfectionsHumansModels, MolecularPeptidesPromoter Regions, GeneticTranscriptional ActivationAnti-Bacterial AgentsPeptidesantibiotic resistancebacterial transcriptioncell-penetrating peptidesDNA-binding proteinsnitrogen starvationstapled peptidesσ factor 54

Identifiers

PMID29887265
PMCPMC6151150
OpenAlexW2806985468

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.