Evidence map›Paper›PMID 29887227›Full record

ArticleAnnals of epidemiology2018

Time-varying coefficient of determination to quantify the explanatory power of biomarkers on longitudinal GFR among children with chronic kidney disease.

Derek K Ng, Anthony A Portale, Susan L Furth, Bradley A Warady, Alvaro Muñoz

Registry-linked trialAbstract read
In one paragraph

Article in Annals of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00327860 (Chronic Kidney Disease in Children Prospective Cohort Study), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00327860 recruitingnot on this map

Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan2003 to 2028Enrolled1,300ConditionsChronic Kidney Disease
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Derek K NgDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Electronic address: dng@jhu.edu.
Anthony A PortaleDivision of Nephrology, Department of Pediatrics, University of California, San Francisco, CA.
Susan L FurthDivision of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA.
Bradley A WaradyDivision of Nephrology, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO.
Alvaro MuñozDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Funding

Chronic Kidney Disease in Children Study (C-Kid)U01DK066174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SUSAN L. FURTH · 2003 to 2026
$25.1M
CKiD Cardiovascular Testing Travel SupplementU01DK066143 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI Bradley Alan Warady · 2003 to 2026
$24.2M
The Kidney Disease in Children Data Management and Analysis Center (KIDMAC)U01DK066116 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MUNOZ, ALVARO · 2003 to 2017
$17.9M
The Kidney Disease in Children Data Management and Analysis Center (KIDMAC)U24DK066116 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Derek K Ng · 2018 to 2026
$12.6M
Central Biochemistry Laboratory of the CKiD ConsortiumU01DK082194 · NIDDK · UNIVERSITY OF ROCHESTER · PI SCHWARTZ, GEORGE J · 2008 to 2017
$3.5M
Central Biochemistry Laboratory of the CKID ConsortiumU24DK082194 · NIDDK · UNIVERSITY OF ROCHESTER · PI SCHWARTZ, GEORGE J · 2018 to 2022
$1.7M
NIDDK NIH HHS U01 DK066116NIDDK NIH HHS U01 DK066143NIDDK NIH HHS U01 DK066174NIDDK NIH HHS U01 DK082194NIDDK NIH HHS U24 DK066116NIDDK NIH HHS U24 DK082194
6 · The paper itself

Abstract

purposeCoefficients of determination (R

methodsUsing longitudinal estimated glomerular filtration rate (eGFR) from the Chronic Kidney Disease in Children Study, linear mixed models characterized the R

resultsTime-varying R

conclusionsProteinuria and FGF23 explained substantial eGFR variability over time. Time-varying R

Indexed as

BiomarkersChildChronic DiseaseDisease ProgressionFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsGlomerular Filtration RateHumansKidney Failure, ChronicLongitudinal StudiesMaleProteinuriaRenal Insufficiency, ChronicBiomarkersFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsChronic kidney diseaseCoefficient of determinationEpidemiologic methodsFibroblast growth factorGlomerular filtration ratePediatricsProteinuria

Identifiers

PMID29887227
PMCPMC6205223

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.