ArticleBiological psychiatry2018
The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System.
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Article in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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40citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- The disappointment centre of the brain gets exciting: a systematic review of habenula dysfunction in depression.Translational psychiatry · 2024Pooled it
- Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial.Translational psychiatry · 2025Trial
- Beyond the role in motor function, entopeduncular nucleus, a critical neural hub in psychiatric disorders and sleep regulation.Annals of medicine · 2026Review
- Increased encoding of aversive stimuli by lateral habenula neurons during ΔNature communications · 2026Article
- Mesohabenular glutamatergic regulation of the consequences of uncontrollable stress.bioRxiv : the preprint server for biology · 2026Article
- Identifying behavioral and biological predictors of cannabis vapor self-administration in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Incretin-Based Therapies: A Novel Pathway in Addiction Treatment.Journal of clinical medicine · 2026Review
- Relationships among peri-traumatic circulating endocannabinoids and long-term, negative outcomes following traumatic injury.Psychopharmacology · 2026Article
- Effects of Repetitive Mild Traumatic Brain Injury on Corticotropin-Releasing Factor Modulation of Lateral Habenula Excitability and Motivated Behavior.Journal of neurotrauma · 2025Article
- Basal forebrain-lateral habenula inputs and control of impulsive behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Brain region specific regulation of anandamide (down) and sphingosine-1-phosphate (up) in association with anxiety (AEA) and resilience (S1P) in a mouse model of chronic unpredictable mild stress.Pflugers Archiv : European journal of physiology · 2024Article
- Functional Adaptation in the Brain Habenulo-Mesencephalic Pathway During Cannabinoid Withdrawal.Cells · 2024Article
- Endocannabinoid concentrations in major depression: effects of childhood maltreatment and relation to hippocampal volume.Translational psychiatry · 2024Article
- Association of semaglutide with reduced incidence and relapse of cannabis use disorder in real-world populations: a retrospective cohort study.Molecular psychiatry · 2024Article
- Effects of Repetitive Mild Traumatic Brain Injury on Corticotropin-Releasing Factor Modulation of Lateral Habenula Excitability and Motivated Behavior.bioRxiv : the preprint server for biology · 2024Article
- Predator odor stress reactivity, alcohol drinking and the endocannabinoid system.Neurobiology of stress · 2024Article
- AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula.Communications biology · 2024Article
- Resilience to substance use disorder following childhood maltreatment: association with peripheral biomarkers of endocannabinoid function and neural indices of emotion regulation.Molecular psychiatry · 2023Article
- Subcortical serotonin 5HTNature communications · 2023Article
- Opposing retrograde and astrocyte-dependent endocannabinoid signaling mechanisms regulate lateral habenula synaptic transmission.Cell reports · 2023Article
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Authors and funding
15 authors at 5 institutions in 3 countries.
Anthony L BergerDepartment of Psychology, Washington State University, Pullman, Washington.
Angela M HenricksDepartment of Psychology, Washington State University, Pullman, Washington.
Janelle M LugoDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington.
Hayden R WrightDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington.
Collin R WarrickDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington.
Martin A StichtDepartment of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Maria MorenaDepartment of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Itziar BonillaDepartment of Neurosciences, University of the Basque Country, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the Universidad del País Vasco/Euskal Herriko Unibertsitatea, Leioa, Spain.
Sarah A LaredoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California.
Rebecca M CraftDepartment of Psychology, Washington State University, Pullman, Washington.
Loren H ParsonsDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California.
Pedro R GrandesDepartment of Neurosciences, University of the Basque Country, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the Universidad del País Vasco/Euskal Herriko Unibertsitatea, Leioa, Spain; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.
Cecilia J HillardDepartment of Pharmacology and Toxicology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Matthew N HillDepartment of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Ryan J McLaughlinDepartment of Psychology, Washington State University, Pullman, Washington; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington. Electronic address: ryan.mclaughlin@wsu.edu.
Washington State University · USAllen Institute for Brain Science · USScripps Research Institute · USUniversity of the Basque Country · ESMedical College of Wisconsin · US
Funding
Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2003 to 2026
$46.3MNeurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4MSYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI KOOB, GEORGE F · 1985 to 2002
$5.1MGene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7MCognitive Function in Alcohol Dependence and Protracted WithdrawalR01AA022249 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARTIN-FARDON, REMI · 2013 to 2017
$2.5MAlcohol dependence and brain endocannabinoid functionR01AA020404 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARTIN-FARDON, REMI · 2011 to 2015
$2.2MGene-environment interaction: the brain CRF system in alcohol preferring msP ratsR01AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2009 to 2013
$1.8MEffects of developmental cannabis exposure on prefrontocortical structure and functionR21DA043722 · NIDA · WASHINGTON STATE UNIVERSITY · PI MCLAUGHLIN, RYAN JOSEPH · 2017 to 2018
$421kEndocannabinoid influence in alcohol dependence-related HPA axis dysregulationF32AA025257 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI LAREDO, SARAH A. · 2016 to 2016
$8kCIHRNIAAA NIH HHS F32 AA025257NIAAA NIH HHS P50 AA006420NIAAA NIH HHS P60 AA006420NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA020404NIAAA NIH HHS R01 AA022249NIAAA NIH HHS R37 AA017447NIAAA NIH HHS T32 AA007456NIDA NIH HHS R21 DA043722
Abstract
backgroundThe ability to effectively cope with stress is a critical determinant of disease susceptibility. The lateral habenula (LHb) and the endocannabinoid (ECB) system have independently been shown to be involved in the selection of stress coping strategies, yet the role of ECB signaling in the LHb remains unknown.
methodsUsing a battery of complementary techniques in rats, we examined the localization of type-1 cannabinoid receptors (CB
resultsElectron microscopy studies revealed CB
conclusionsAlterations in LHb ECB signaling may be relevant for development of stress-related pathologies in which LHb dysfunction and stress-coping impairments are hallmark symptoms.
Indexed as
Adaptation, PsychologicalMaze LearningSpatial MemoryAnimalsArachidonic AcidsCannabinoid Receptor AgonistsCorticosteroneDepressionDisease Models, AnimalEndocannabinoidsFemaleGlyceridesHabenulaMaleMiceMice, Inbred C57BLArachidonic AcidsCannabinoid Receptor AgonistsCorticosteroneEndocannabinoidsGlyceridesglyceryl 2-arachidonateReceptor, Cannabinoid, CB1AnxietyCB(1) receptorEndocannabinoidLateral habenulaRatStress coping
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