Evidence map›Paper›PMID 29886893›Full record

ArticleProstaglandins, leukotrienes, and essential fatty acids2018

A rare eicosanoid precursor analogue, sciadonic acid (5Z,11Z,14Z-20:3), detected in vivo in hormone positive breast cancer tissue.

H G Park, J Y Zhang, C Foster, D Sudilovsky, D A Schwed, J Mecenas, S Devapatla, P Lawrence, K S D Kothapalli, J T Brenna

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostaglandins, leukotrienes, and essential fatty acids, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

H G ParkDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA; Dell Pediatric Research Institute and Dept. of Pediatrics, Dell Medical School, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA.
J Y ZhangDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
C FosterCayuga Medical Center, 101 Dates Drive, Ithaca, NY 14850, USA.
D SudilovskyCayuga Medical Center, 101 Dates Drive, Ithaca, NY 14850, USA.
D A SchwedCayuga Medical Center, 101 Dates Drive, Ithaca, NY 14850, USA.
J MecenasCayuga Medical Center, 101 Dates Drive, Ithaca, NY 14850, USA.
S DevapatlaCayuga Medical Center, 101 Dates Drive, Ithaca, NY 14850, USA.
P LawrenceDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
K S D KothapalliDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA; Dell Pediatric Research Institute and Dept. of Pediatrics, Dell Medical School, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA. Electronic address: kkothapalli@utexas.edu.
J T BrennaDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA; Dell Pediatric Research Institute and Dept. of Pediatrics, Dell Medical School, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA; Department of Chemistry, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA. Electronic address: tbrenna@utexas.edu.
Cornell University · USIthaca College · US

Funding

Molecular mechanism of omega-3 responseR01AT007003 · NCCIH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRENNA, JAMES T. · 2013 to 2017
$1.9M
NCCIH NIH HHS R01 AT007003
6 · The paper itself

Abstract

Numerous genetic alterations of HSA 11q13 are found frequently in several cancer types, including breast cancer (BC). The 11q13 locus harbors FADS2 encoding Δ6 desaturation which is not functional in several cancer cell lines, including hormone positive MCF7 BC cells. In vitro, the non-functional FADS2 activity unmasks 18:2n-6 elongation to 20:2n-6 and Δ5 desaturation by FADS1 to yield 5Z,11Z,14Z-20:3 (sciadonic acid) rather than 5Z,8Z,11Z,14Z-20:4 (arachidonic acid). In this pilot study we aimed to determine whether 5,11,14-20:3 appears in vivo in hormone positive human BC tissue. Fatty acids were profiled in surgically removed human breast tumor and adjacent normal tissue (n = 9). Sciadonic acid was detected in three of nine breast tumor samples and was below detect limits in normal breast tissue. The internal Δ8 double bond of arachidonic acid is required for normal eicosanoid synthesis but is missing in sciadonic acid. This pilot study demonstrates for the first time in vivo sciadonic acid in hormone positive BC tissue, warranting a larger survey study to further evaluate its appearance and the functional implications.

Indexed as

AnimalsArachidonic AcidsBreastBreast NeoplasmsChromatography, GasDelta-5 Fatty Acid DesaturaseFatty Acid DesaturasesFemaleHumansMastectomyMCF-7 CellsMicePilot ProjectsSwiss 3T3 CellsArachidonic AcidsDelta-5 Fatty Acid Desaturaseeicosa-5,11,14-trienoic acidFADS1 protein, humanFADS2 protein, humanFatty Acid DesaturasesBreast cancerCell signalingDocosanoidEicosanoidEstrogenFatty acid desaturase 2

Identifiers

PMID29886893
PMCPMC5999340
OpenAlexW2803441129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.