Evidence map›Paper›PMID 29886802›Full record

ArticleCell cycle (Georgetown, Tex.)2018

R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells.

Jun Ye, Shanxi Liu, Yangyang Shang, Haoyuan Chen, Rongquan Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jun Yea Institute of Gastroenterology of PLA, Southwest Hospital , Third Military Medical University , Chongqing , China.
Shanxi Liua Institute of Gastroenterology of PLA, Southwest Hospital , Third Military Medical University , Chongqing , China.
Yangyang Shanga Institute of Gastroenterology of PLA, Southwest Hospital , Third Military Medical University , Chongqing , China.
Haoyuan Chena Institute of Gastroenterology of PLA, Southwest Hospital , Third Military Medical University , Chongqing , China.
Rongquan Wanga Institute of Gastroenterology of PLA, Southwest Hospital , Third Military Medical University , Chongqing , China.
Southwest Hospital · CNArmy Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Wnt signaling pathway controls stem cell identity in the intestinal epithelium and cancer stem cells (CSCs). The transcription factor Ascl2 (Wnt target gene) is fate decider of intestinal cryptic stem cells and colon cancer stem cells. It is unclear how Wnt signaling is translated into Ascl2 expression and keeping the self-renewal of CRC progenitor cells. We showed that the exogenous Ascl2 in colorectal cancer (CRC) cells activated the endogenous Ascl2 expression via a direct autoactivatory loop, including Ascl2 binding to its own promoter and further transcriptional activation. Higher Ascl2 expression in human CRC cancerous tissues led to greater enrichment in Ascl2 immunoprecipitated DNA within the Ascl2 promoter in the CRC cancerous sample than the peri-cancerous mucosa. Ascl2 binding to its own promoter and inducing further transcriptional activation of the Ascl2 gene was predominant in the CD133

Indexed as

Cell Self RenewalHomeostasisAntigens, CDBasic Helix-Loop-Helix ProteinsCell Line, TumorColonic NeoplasmsGene Expression Regulation, NeoplasticHumansModels, BiologicalNeoplastic Stem CellsPromoter Regions, GeneticRNA, MessengerR-SpondinsSpheroids, CellularThrombospondinsTranscriptional ActivationAntigens, CDASCL2 protein, humanBasic Helix-Loop-Helix ProteinsRNA, MessengerRSPO1 protein, humanR-SpondinsThrombospondinsAchaete scute-like 2AutoregulationColorectal cancerProgenitor cellSelf-renewalWnt signaling

Identifiers

PMID29886802
PMCPMC6103697
OpenAlexW2805396414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.