Evidence map›Paper›PMID 29886767›Full record

ReviewAIDS research and human retroviruses2018

CD4-HIV-1 Envelope Interactions: Critical Insights for the Simian/HIV/Macaque Model.

Amit Sharma, Julie Overbaugh

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in AIDS research and human retroviruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amit Sharma1 Division of Human Biology, Fred Hutchinson Cancer Research Center , Seattle, Washington.
Julie Overbaugh1 Division of Human Biology, Fred Hutchinson Cancer Research Center , Seattle, Washington.
Fred Hutch Cancer Center · US

Funding

TOWARDS A MORE RELEVANT MODEL OF HIV INFECTIONDP1DA039543 · NIDA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI OVERBAUGH, JULIE M. · 2015 to 2019
$4.4M
Host innate immune response as a barrier to cross-species retrovirus transmissionR00AI125136 · NIAID · OHIO STATE UNIVERSITY · PI SHARMA, AMIT · 2019 to 2020
$498k
Host Innate Immune Response as a Barrier to Cross-Species Retrovirus TransmissionK99AI125136 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SHARMA, AMIT · 2016 to 2017
$194k
NIAID NIH HHS K99 AI125136NIAID NIH HHS R00 AI125136NIDA NIH HHS DP1 DA039543
6 · The paper itself

Abstract

The macaque models of HIV-1 infection have been a cornerstone of research on transmission, pathogenesis, and prevention. In particular, the infection of macaques with chimeric simian/HIV-1 viruses (SHIVs) is central to the vaccine development pipeline because SHIVs encode the key target of HIV-1-neutralizing antibodies, the HIV-1 envelope (env) protein. In this review, we highlight some of the recent studies that have improved our understanding of the CD4-HIV-1 env interaction, which are crucial for development of SHIV/macaque models of HIV-1 infection.

Indexed as

AnimalsAntibodies, NeutralizingCD4-Positive T-LymphocytesDisease Models, Animalenv Gene Products, Human Immunodeficiency VirusHIV-1HIV InfectionsHIV SeropositivityMacaca mulattaSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAntibodies, Neutralizingenv Gene Products, Human Immunodeficiency VirusCD4HIV-1 envelopeSHIV/macaque model

Identifiers

PMID29886767
PMCPMC6152845
OpenAlexW2807983529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.