ArticleEnvironment international2018
Maternal ambient heat exposure during early pregnancy in summer and spring and congenital heart defects - A large US population-based, case-control study.
Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A systematic review and meta-analysis on heat thresholds for maternal health and birth outcomes.Nature communications · 2026Pooled it
- Impact of exposure to extreme heat events during pregnancy on the incidence of congenital heart disease in offspring: a meta-analysis.BMJ paediatrics open · 2024Pooled it
- Prenatal ambient temperature and risk for schizophrenia.Schizophrenia research · 2022Pooled it
- Impacts of High Environmental Temperatures on Congenital Anomalies: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Associations between extreme temperature events and daily step counts by weight status and modifying effects of sociodemographic factors: a longitudinal study.The American journal of clinical nutrition · 2026Article
- Understanding Heat Exposure Risks and Adaptation Behaviors Among Elderly Asian Communities in New York City.Urban climate · 2025Article
- Article
- Differential Effects of Green Space Typologies on Congenital Anomalies: Data from the Korean National Health Insurance Service (2008-2013).Healthcare (Basel, Switzerland) · 2025Article
- The Influence of Heat on Pediatric and Perinatal Health: Risks, Evidence, and Future Directions.Journal of clinical medicine · 2025Review
- Development and validation of an epidemiological risk score for neonatal death in a middle-income country.Frontiers in public health · 2025Article
- Impact of extreme temperature on congenital heart disease mortality: a population-based nationwide case-crossover study.The Lancet regional health. Western Pacific · 2024Article
- Exposure to acute ambient temperature extremes and neonatal intensive care unit admissions: A case-crossover study.The Science of the total environment · 2024Article
- Strengthening Maternal and Infant Health Resilience Before Weather and Climate Disasters: Preparedness Resources from CDC's Division of Reproductive Health.Journal of women's health (2002) · 2024Article
- Season, household registry and isolated birth defects: a population-based case-control study in Danyang, China.International health · 2024Article
- Environmental Exposures and Pediatric Cardiology: A Scientific Statement From the American Heart Association.Circulation · 2024Review
- Ambient heat and diabetes hospitalizations: Does the timing of heat exposure matter?The Science of the total environment · 2024Article
- Examining modification of the associations between air pollution and birth outcomes by neighborhood deprivation in a North Carolina birth cohort, 2011-2015.Frontiers in reproductive health · 2024Article
- Association between First Trimester Exposure to AmbientEnvironmental health perspectives · 2023Article
- Assessing associations between residential proximity to greenspace and birth defects in the National Birth Defects Prevention Study.Environmental research · 2023Article
- Interaction of maternal medication use with ambient heat exposure on congenital heart defects in the National Birth Defects Prevention Study.Environmental research · 2022Article
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Authors and funding
21 authors.
Funding
Abstract
BACKGROUND/
objectiveFew studies have assessed the effect of ambient heat during the fetal development period on congenital heart defects (CHDs), especially in transitional seasons. We examined and compared the associations between extreme heat and CHD phenotypes in summer and spring, assessed their geographical differences, and compared different heat indicators.
methodsWe identified 5848 CHD cases and 5742 controls (without major structural defects) from the National Birth Defects Prevention Study, a US multicenter, population-based case-control study. Extreme heat events (EHEs) were defined by using the 95th (EHE95) or 90th (EHE90) percentile of daily maximum temperature and its frequency and duration during postconceptional weeks 3-8. We used a two-stage Bayesian hierarchical model to examine both regional and study-wide associations. Exposure odds ratios (ORs) were calculated using multivariate logistic regression analyses, while controlling for potential confounding factors.
resultsOverall, we observed no significant relationships between maternal EHE exposure and CHDs in most regions during summer. However, we found that 3-11 days of EHE90 during summer and spring was significantly associated with ventricular septal defects (VSDs) study-wide (ORs ranged: 2.17-3.24). EHE95 in spring was significantly associated with conotruncal defects and VSDs in the South (ORs: 1.23-1.78). Most EHE indicators in spring were significantly associated with increased septal defects (both VSDs and atrial septal defects (ASDs)) in the Northeast.
conclusionWhile generally null results were found, long duration of unseasonable heat was associated with the increased risks for VSDs and ASDs, mainly in South and Northeast of the US. Further research to confirm our findings is needed.
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