ArticleThe Journal of urology2018
Long-Term Cancer Specific Anxiety in Men Undergoing Active Surveillance of Prostate Cancer: Findings from a Large Prospective Cohort.
Article in The Journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Fear of cancer recurrence and PSA anxiety in patients with prostate cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- The effectiveness of psychological intervention for depression, anxiety, and distress in prostate cancer: a systematic review of literature.Prostate cancer and prostatic diseases · 2021Pooled it
- Interventions that Facilitate Shared Decision-Making in Cancers with Active Surveillance as Treatment Option: a Systematic Review of Literature.Current oncology reports · 2020Pooled it
- STHLM3 NorDCaP: prospective multicentre trial of Stockholm3 for active surveillance biopsy guidance.BJU international · 2026Trial
- Trial
- Impact of Clinicopathological and Institutional Factors on the Clinical Courses of Patients With Localized Prostate Cancer Initially Managed by Active Surveillance: An Analysis of Nationwide Real-World Data From Japan.International journal of urology : official journal of the Japanese Urological Association · 2026Observational
- Active Surveillance for Low- and Favourable Intermediate-Risk Prostate Cancer: A Single-Centre Cohort Study on Discontinuation Rates and Quality-of-Life Outcomes.Journal of personalized medicine · 2026Article
- Analytical Validation of MyProstateScore 2.0-Active Surveillance: A Urinary-Based Clinical RT-PCR Prostate Cancer Assay.Diagnostics (Basel, Switzerland) · 2026Article
- Quality of life in low-risk prostate cancer under active surveillance or following radical treatments: the START cohort study.Prostate cancer and prostatic diseases · 2026Article
- Latent profile analysis of fear of cancer recurrence in patients with prostate cancer: Insights into risk factors and psychological interventions.Asia-Pacific journal of oncology nursing · 2025Article
- Key Determinants Influencing Treatment Decision-Making for and Adherence to Active Surveillance for Prostate Cancer: A Systematic Review.Journal of personalized medicine · 2025Review
- The lived experience of prostate cancer: 10-year survivor perspectives following contemporary treatment of localized prostate cancer.Journal of cancer survivorship : research and practice · 2024Article
- Characteristics Predicting Short-Term and Long-Term Health-Related Quality of Life in Patients with Esophageal Cancer After Neoadjuvant Chemoradiotherapy and Esophagectomy.Annals of surgical oncology · 2023Article
- Fear of Cancer Recurrence and Coping Strategies among Prostate Cancer Survivors: A Qualitative Study.Current oncology (Toronto, Ont.) · 2023Article
- Mindfulness-based stress reduction for men on active surveillance for prostate cancer and their spouses: Design and methodology of a randomized controlled trial.Contemporary clinical trials · 2023Article
- Prostate cancer-related anxiety among long-term survivors after radical prostatectomy: A longitudinal study.Cancer medicine · 2023Article
- Selecting interventions for a psychosocial support program for prostate cancer patients undergoing active surveillance: A modified Delphi study.Psycho-oncology · 2022Review
- Diet and Health-related Quality of Life Among Men on Active Surveillance for Early-stage Prostate Cancer: The Men's Eating and Living Study (Cancer and Leukemia Group 70807 [Alliance]).European urology focus · 2022Article
- Active Surveillance in Intermediate-Risk Prostate Cancer: A Review of the Current Data.Cancers · 2022Review
- Impact of active surveillance for prostate cancer on the risk of depression and anxiety.Scientific reports · 2022Article
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Funding
Abstract
purposeActive surveillance is the preferred management of low risk prostate cancer. Cancer specific anxiety during active surveillance remains under studied. We evaluated long-term anxiety in men on active surveillance to determine whether interventions must be tailored to improve adherence. MATERIALS AND
methodsA total of 413 men enrolled in active surveillance at a single tertiary care center completed quality of life surveys as part of routine care. A modified version of the MAX-PC (Memorial Anxiety Scale for Prostate Cancer) was used to determine cancer specific anxiety. Generalized estimating equations were applied to evaluate the association between anxiety and the duration on surveillance. Additionally, we examined associations between anxiety and patient age, marital status, Gleason score, the number of positive cores, family history and overall health.
resultsMedian patient age was 61 years, median prostate specific antigen at diagnosis was 4.4 ng/ml and 95% of the patients had Gleason 6 disease. Median time from the initiation of active surveillance to the last survey was 3.7 years. There was a 29% risk of reporting cancer specific anxiety within year 1. Anxiety significantly decreased with time (OR 0.87, 95% CI 0.79-0.95, p = 0.003). Pathological and demographic characteristics were not associated with anxiety after adjusting for time on surveillance.
conclusionsIn men undergoing active surveillance we observed a moderate risk of cancer specific anxiety which significantly decreases with time. Those considering conservative management can be informed that, although it is common to experience some anxiety initially, most patients rapidly adjust and report low anxiety levels within 2 years.
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