Evidence map›Paper›PMID 29885938›Full record

ArticleBrazilian journal of anesthesiology (Elsevier)

[Does dexmedetomidine prevent colistin nephrotoxicity?]

Gamze Talih, Aliye Esmaoğlu, Adnan Bayram, Cevat Yazici, Kemal Deniz, Tutkun Talih

Open access · diamondAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Rat models of colistin nephrotoxicity: previous experimental researches and future perspectives.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gamze TalihAkcakale State Hospital, Department of Anesthesiology and Reanimation, Şanlıurfa, Turquia.
Aliye EsmaoğluErciyes University, Medical Faculty, Department of Anesthesiology and Reanimation, Kayseri, Turquia. Electronic address: ealiye@erciyes.edu.tr.
Adnan BayramErciyes University, Medical Faculty, Department of Anesthesiology and Reanimation, Kayseri, Turquia.
Cevat YaziciErciyes University, Medical Faculty, Department of Biochemistry, Kayseri, Turquia.
Kemal DenizErciyes University, Medical Faculty, Department of Pathology, Kayseri, Turquia.
Tutkun TalihAkcakale State Hospital, Department of General Surgery, Şanlıurfa, Turquia.
Erciyes University · TRSivas State Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we aimed to investigate the effect of dexmedetomidine on colistin nephrotoxicity in rats.

methodsThirty-two Wistar albino rats were allocated into four groups. Intraperitoneal (ip) saline at 1mL.kg

resultsThe values for BUN, Cr and TOS were significantly higher in the colistin group than in the control group. BUN, Cr and TOS changes in the DEX10 and DEX20 groups were not significant compared with the control group but they were significantly lower compared with the colistin group. TAS values in the DEX10 group were significantly lower than in the control group. Apoptotic activity was significantly higher in the colistin group compared with the control group, but there was no significant difference in terms of caspase-3 staining activity when DEX10 and DEX20 groups were compared with the control group.

conclusionOxidative damage and apoptosis played roles in colistin nephrotoxicity, and colistin nephrotoxicity could be prevented by treatment with dexmedetomidine.

Indexed as

Alpha‐2 agonistAlpha‐2 agonistaColistinColistinaColistin nephrotoxicityDexmedetomidinaDexmedetomidineNefrotoxicidade da colistina

Identifiers

PMID29885938
PMCPMC9391814
OpenAlexW2793131114

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.