Evidence map›Paper›PMID 29885858›Full record

Trial reportBrain stimulation

Transcranial direct current brain stimulation decreases impulsivity in ADHD.

Cheyenne Allenby, Mary Falcone, Leah Bernardo, E Paul Wileyto, Anthony Rostain, J Russell Ramsay, Caryn Lerman, James Loughead

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01876524 (Transcranial Random Noise Stimulation in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology Patients), which is not on this map. Cited by 57 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01876524 nacompletednot on this map

Transcranial Random Noise Stimulation in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology Patients

TypeinterventionalSponsorSpanish Foundation for Neurometrics DevelopmentRan2013 to 2014Enrolled225ConditionsSubstance Use Disorder, Attention Deficit Disorder With Hyperactivity, Bipolar Disorder, SchizophreniaArmsTranscranial Random Noise Stimulation
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  17. Does transcranial direct current stimulation enhance cognitive performance in Parkinson's disease mild cognitive impairment? An event-related potentials and neuropsychological assessment study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cheyenne AllenbyCenter for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Mary FalconeCenter for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Leah BernardoCenter for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
E Paul WileytoDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.
Anthony RostainAdult ADHD Treatment and Research Program, University of Pennsylvania, Philadelphia, PA, USA.
J Russell RamsayAdult ADHD Treatment and Research Program, University of Pennsylvania, Philadelphia, PA, USA.
Caryn LermanCenter for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
James LougheadCenter for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: loughead@upenn.edu.

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8M
Neuroscience-based Interventions for Cancer Risk Behavior ChangeR35CA197461 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LERMAN, CARYN · 2015 to 2021
$6.0M
NCI NIH HHS P30 CA016520NCI NIH HHS R35 CA197461NIGMS NIH HHS T32 GM008076
6 · The paper itself

Abstract

backgroundImpulsivity is a core deficit in attention deficit hyperactivity disorder (ADHD). Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) has been shown to modulate cognitive control circuits and could enhance DLPFC activity, leading to improved impulse control in ADHD.

objectiveHypothesis: We predicted 2.0 mA anodal stimulation (tDCS) versus sham stimulation applied over the left DLPFC would improve Conners Continuous Performance Task (CPT) scores. Our secondary hypothesis predicted that stop signal task (SST) reaction time (SSRT) would decrease with tDCS (versus sham).

methodsThirty-seven participants completed two periods of three tDCS (or sham) sessions two weeks apart in a within-subject, double-blind, counterbalanced order. Participants performed a fractal N-back training task concurrent with tDCS (or sham) stimulation. Participants completed the CPT and SST at the beginning of treatment (baseline), at the end of the treatment, and at a 3-day post-stimulation follow-up.

resultsThere was a significant stimulation condition by session interaction for CPT false positive scores (χ

conclusionThese findings suggest that stimulation of the left DLPFC with tDCS can improve impulsivity symptoms in ADHD, supporting the therapeutic potential for tDCS in adult ADHD patients.

Indexed as

AdultAttentionAttention Deficit Disorder with HyperactivityCognitionCross-Over StudiesDouble-Blind MethodFemaleFollow-Up StudiesHumansImpulsive BehaviorMaleNeuropsychological TestsPrefrontal CortexReaction TimeTranscranial Direct Current StimulationAttention deficit hyperactivity disorderContinuous performance taskDorsolateral prefrontal cortexImpulsivitytDCS

Identifiers

PMID29885858
PMCPMC6109423

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.