ArticleBiological psychiatry2018
A Longitudinal Imaging Genetics Study of Neuroanatomical Asymmetry in Alzheimer's Disease.
Article in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Interaction Analysis Reveals Complex Genetic Associations with Alzheimer's Disease in theGenes · 2023Pooled it
- Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.Molecular psychiatry · 2022Pooled it
- Whole body CT attenuation and volume charts from routine clinical scans via LLM report filtering.NPJ digital medicine · 2026Article
- Brain functional specialization and cooperation in Alzheimer's disease.Brain and behavior · 2024Article
- ABCA7-Associated Clinical Features and Molecular Mechanisms in Alzheimer's Disease.Molecular neurobiology · 2023Review
- Shared genetic architecture between attention-deficit/hyperactivity disorder and lifespan.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Revealing the correlations between brain cortical characteristics and susceptibility genes for Alzheimer disease: a cross-sectional study.Quantitative imaging in medicine and surgery · 2023Article
- Altered cortical and subcortical morphometric features and asymmetries in the subjective cognitive decline and mild cognitive impairment.Frontiers in neurology · 2023Article
- Modern views of machine learning for precision psychiatry.Patterns (New York, N.Y.) · 2022Review
- Article
- Changes in and asymmetry of the proteome in the human fetal frontal lobe during early development.Communications biology · 2022Article
- Mapping Complex Brain Torque Components and Their Genetic Architecture and Phenomic Associations in 24,112 Individuals.Biological psychiatry · 2022Article
- Lessons from behavioral lateralization in olfaction.Brain structure & function · 2022Review
- A Deficiency of the Psychiatric Risk Gene DLG2/PSD-93 Causes Excitatory Synaptic Deficits in the Dorsolateral Striatum.Frontiers in molecular neuroscience · 2022Article
- Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models.Neurobiology of disease · 2021Review
- Body Mass Index and Polygenic Risk for Alzheimer's Disease Predict Conversion to Alzheimer's Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Role of ABCA7 in Human Health and in Alzheimer's Disease.International journal of molecular sciences · 2021Review
- Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus).Scientific reports · 2021Article
- A Systems Biology Approach for Hypothesizing the Effect of Genetic Variants on Neuroimaging Features in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Article
- Lateralization of Motor Signs Affects Symptom Progression in Parkinson Disease.Frontiers in neurology · 2021Article
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6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundContralateral brain structures represent a unique, within-patient reference element for disease, and asymmetries can provide a personalized measure of the accumulation of past disease processes. Neuroanatomical shape asymmetries have recently been associated with the progression of Alzheimer's disease (AD), but the biological basis of asymmetric brain changes in AD remains unknown.
methodsWe investigated genetic influences on brain asymmetry by identifying associations between magnetic resonance imaging-derived measures of asymmetry and candidate single nucleotide polymorphisms (SNPs) that have previously been identified in genome-wide association studies for AD diagnosis and for brain subcortical volumes. For analyzing longitudinal neuroimaging data (1241 individuals, 6395 scans), we used a mixed effects model with interaction between genotype and diagnosis.
resultsSignificant associations between asymmetry of the amygdala, hippocampus, and putamen and SNPs in the genes BIN1, CD2AP, ZCWPW1, ABCA7, TNKS, and DLG2 were found.
conclusionsThe associations between SNPs in the genes TNKS and DLG2 and AD-related increases in shape asymmetry are of particular interest; these SNPs have previously been associated with subcortical volumes of amygdala and putamen but have not yet been associated with AD pathology. For AD candidate SNPs, we extend previous work to show that their effects on subcortical brain structures are asymmetric. This provides novel evidence about the biological underpinnings of brain asymmetry as a disease marker.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.