ReviewAutoimmunity reviews2018
Impact of obesity on autoimmune arthritis and its cardiovascular complications.
Review in Autoimmunity reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Improvements in cholesterol efflux capacity of HDL after bariatric surgery in patients with obesity: a meta-analysis.BMC surgery · 2025Pooled it
- Efficacy and Safety of CKDB-322, a Combination ofNutrients · 2026Trial
- Longitudinal patterns of obesity index changes and risk of incident rheumatoid arthritis: evidence from a population-based cohort.Arthritis research & therapy · 2025Article
- Association Between T2DM, TyG Index, Multiple Sclerosis, and Rheumatoid Arthritis: Insights into Potential Mechanisms.Molecular neurobiology · 2025Article
- Article
- Prevalence of Metabolic Syndrome and Autoimmune Markers in Adults: A Cross-Sectional Study From Türkiye.International journal of endocrinology · 2025Article
- Lipid-Lowering and Anti-Inflammatory Effects ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Association between different triglyceride-glucose index combinations with obesity indicators and arthritis: results from two nationally representative population-based study.European journal of medical research · 2024Article
- Cross-sectional associations of low body mass index and being underweight with joint damage in Chinese patients with rheumatoid arthritis.Rheumatology advances in practice · 2024Article
- Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis.EMBO reports · 2023Article
- Investigating the shared genetic architecture between hypothyroidism and rheumatoid arthritis.Frontiers in immunology · 2023Article
- Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR Expression.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Impact of obesity on quality of life, psychological status, and disease activity in psoriatic arthritis: a multi‑center study.Rheumatology international · 2022 · on this mapArticle
- The Combination of Intestinal Alkaline Phosphatase Treatment with Moderate Physical Activity Alleviates the Severity of Experimental Colitis in Obese Mice via Modulation of Gut Microbiota, Attenuation of Proinflammatory Cytokines, Oxidative Stress Biomarkers and DNA Oxidative Damage in Colonic Mucosa.International journal of molecular sciences · 2022Article
- Jian Pi Tiao Gan Yin alleviates obesity phenotypes through mTORC1/SREBP1 signalingAnnals of translational medicine · 2022Article
- Impact of the malnutrition on mortality in Rheumatoid arthritis patients: A cohort study from NHANES 1999-2014.Frontiers in nutrition · 2022Article
- Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity.JID innovations : skin science from molecules to population health · 2022Review
- Causal Links between Hypovitaminosis D and Dysregulation of the T Cell Connection of Immunity Associated with Obesity and Concomitant Pathologies.Biomedicines · 2021Review
- Molecular Changes in the Adipose Tissue Induced by Rheumatoid Arthritis: Effects of Disease-Modifying Anti-Rheumatic Drugs.Frontiers in immunology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Obesity can instigate and sustain a systemic low-grade inflammatory environment that can amplify autoimmune disorders and their associated comorbidities. Metabolic changes and inflammatory factors produced by the adipose tissue have been reported to aggravate autoimmunity and predispose the patient to cardiovascular disease (CVD) and metabolic comorbidities. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are autoimmune arthritic diseases, often linked with altered body mass index (BMI). Severe joint inflammation and bone destruction have a debilitating impact on the patient's life; there is also a staggering risk of cardiovascular morbidity and mortality. Furthermore, these patients are at risk of developing metabolic symptoms, including insulin resistance resulting in type 2 diabetes mellitus (T2DM). In addition, arthritis severity, progression and response to therapy can be markedly affected by the patient's BMI. Hence, a complex integrative pathogenesis interconnects autoimmunity with metabolic and cardiovascular disorders. This review aims to shed light on the network that connects obesity with RA, PsA, systemic lupus erythematosus and Sjӧgren's syndrome. We have focused on clarifying the mechanism by which obesity affects different cell types, inflammatory factors and traditional therapies in these autoimmune disorders. We conclude that to further optimize arthritis therapy and to prevent CVD, it is imperative to uncover the intricate relation between obesity and arthritis pathology.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.