ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2018
Racial Disparities in Lung Cancer Survival: The Contribution of Stage, Treatment, and Ancestry.
Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- A systematic review of genetic ancestry as a risk factor for incidence of non-small cell lung cancer in the US.Frontiers in genetics · 2023Pooled it
- Article
- Non-Small Cell Lung Cancer Survival by Race and Ethnicity in California, 2014-2019 Differences by Sex and Smoking History.CHEST pulmonary · 2025Article
- Presenting Features and Causes of Diagnostic Delays: A Report From the NUT Carcinoma Registry.JCO precision oncology · 2025Article
- Racial disparities in the cause of death among patients with lung cancer in the United States.Journal of thoracic disease · 2025Article
- Review
- Perceptions of Smoking Stigma Among African Americans: A Qualitative Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Equity and Opportunities in Lung Cancer Care-Addressing Disparities, Challenges, and Pathways Forward.Cancers · 2025Review
- Racial Disparities in Cancer Guideline-Concordant Treatment Using Surveillance, Epidemiology, and End Results Data for Patients With NSCLC.JTO clinical and research reports · 2025Article
- Develop a prognostic and drug therapy efficacy prediction model for hepatocellular carcinoma based on telomere maintenance-associated genes.Frontiers in oncology · 2025Article
- Disparities in Lung Cancer: A Targeted Literature Review Examining Lung Cancer Screening, Diagnosis, Treatment, and Survival Outcomes in the United States.Journal of racial and ethnic health disparities · 2024Review
- Article
- Assessing a Polygenic Risk Score for Lung Cancer Susceptibility in Non-Hispanic White and Black Populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Health Equity in Patients Receiving Durvalumab for Unresectable Stage III Non-Small Cell Lung Cancer in the US Veterans Health Administration.The oncologist · 2023Article
- Article
- Assessing how lung cancer screening guidelines contribute to racial disparities in screening access.Translational lung cancer research · 2023Article
- Racial Disparities in Lung Cancer Stage of Diagnosis Among Adults Living in the Southeastern United States.Chest · 2023Observational
- The Lack of Race and Ethnicity Data in Australia-A Threat to Achieving Health Equity.International journal of environmental research and public health · 2023Review
- Racial, Ethnic, and Socioeconomic Characteristics Independently Predict for Cachexia Risk and Associated Survival Outcomes in Stage IV NSCLC: A Brief Report.JTO clinical and research reports · 2023Article
- Lung Cancer Mortality in the United States between 1999 and 2019: An Observational Analysis of Disparities by Sex and Race.Annals of the American Thoracic Society · 2023Observational
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
introductionLung cancer is a leading cause of cancer-related death worldwide. Racial disparities in lung cancer survival exist between blacks and whites, yet they are limited by categorical definitions of race. We sought to examine the impact of African ancestry on overall survival among blacks and whites with NSCLC cases.
methodsIncident cases of NSCLC in blacks and whites from the prospective Southern Community Cohort Study (N = 425) were identified through linkage with state cancer registries in 12 southern states. Vital status was determined by linkage with the National Death Index and Social Security Administration. We evaluated the impact of African ancestry (as estimated by using genome-wide ancestry-informative markers) on overall survival by calculating the time-dependent area under the curve (AUC) for Cox proportional hazards models, adjusting for relevant covariates such as stage and treatment. We replicated our findings in an independent population of NSCLC cases in blacks.
resultsGlobal African ancestry was not significantly associated with overall survival among NSCLC cases. There was no change in model performance when Cox proportional hazards models with and without African ancestry were compared (AUC = 0.79 for each model). Removal of stage and treatment reduced the average time-dependent AUC from 0.79 to 0.65. Similar findings were observed in our replication study.
conclusionsStage and treatment are more important predictors of survival than African ancestry is. These findings suggest that racial disparities in lung cancer survival may disappear with similar early detection efforts for blacks and whites.
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Registered trials
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