Evidence map›Paper›PMID 29885378›Full record

ArticleAntiviral research2018

Long-acting parenteral combination antiretroviral loaded nano-drug delivery system to treat chronic HIV-1 infection: A humanized mouse model study.

Subhra Mandal, Guobin Kang, Pavan Kumar Prathipati, Wenjin Fan, Qingsheng Li, Christopher J Destache

Abstract read
In one paragraph

Article in Antiviral research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
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  8. Virus-Mimicking Polymer Nanoparticles Targeting CD169ACS applied materials & interfaces · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Subhra MandalSchool of Pharmacy & Health Professions, Creighton University, Omaha, NE 68178, USA. Electronic address: SubhraMandal@creighton.edu.
Guobin KangCenter for Virology, University of Nebraska-Lincoln, 4240 Fair St, Lincoln, NE 68583, USA.
Pavan Kumar PrathipatiSchool of Pharmacy & Health Professions, Creighton University, Omaha, NE 68178, USA.
Wenjin FanCenter for Virology, University of Nebraska-Lincoln, 4240 Fair St, Lincoln, NE 68583, USA.
Qingsheng LiCenter for Virology, University of Nebraska-Lincoln, 4240 Fair St, Lincoln, NE 68583, USA.
Christopher J DestacheSchool of Pharmacy & Health Professions, Creighton University, Omaha, NE 68178, USA; School of Medicine, Division of Infectious Diseases, Creighton University, Omaha, NE 68178, USA.

Funding

Long-acting antiretroviral nanoparticles for HIV prophylaxisR01AI117740 · NIAID · CREIGHTON UNIVERSITY · PI DESTACHE, CHRISTOPHER J · 2015 to 2018
$2.1M
NIAID NIH HHS R01 AI117740
6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) patients are often diagnosed in the chronic stage of HIV/AIDS. Combination antiretroviral therapy (cART) has improved quality of life for HIV-infected patients. Present study describes a novel long-acting parenteral formulation of combination antiretroviral (cARV) loaded nano-drugs for treating chronic HIV-1 (cHIV) in a humanized-BLT (hu-BLT) mice model. The cARV (elvitegravir+tenofovir alafenamide+emtricitabine; EVG+TAF+FTC) drugs (mimicking marketed Genvoya

Indexed as

Drug Delivery SystemsAnimalsAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveDelayed-Action PreparationsDisease Models, AnimalHIV-1HIV InfectionsHumansInjections, SubcutaneousMiceNanostructuresPlasmaTreatment OutcomeViral LoadAnti-Retroviral AgentsDelayed-Action PreparationsCombination antiretroviral drugsElvitegravirEmtricitabineHIV-1 treatmentHumanized mice modelNanoparticlesTenofovir alafenamide

Identifiers

PMID29885378
PMCPMC7226910

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.