Evidence map›Paper›PMID 29885356›Full record

ArticleFree radical biology & medicine2018

LAURDAN fluorescence and phasor plots reveal the effects of a H

Leonel Malacrida, Enrico Gratton

Abstract read
In one paragraph

Article in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 48 citations in OpenAlex.

  1. Laurdan: Clarifying Photophysics and Advancing the Characterization of Extracellular Vesicles.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
    Article
  2. Review
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  9. Review
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  11. Laurdan Discerns Lipid Membrane Hydration and Cholesterol Content.The journal of physical chemistry. B · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Leonel MalacridaLaboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, 3208 Natural Sciences II, Irvine, CA 92697‑2715, USA; Área de Investigación Respiratoria, Departamento de Fisiopatología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Av. Italia s/n, Piso 15, Montevideo 11600, Uruguay. Electronic address: lmalacri@uci.edu.
Enrico GrattonLaboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, 3208 Natural Sciences II, Irvine, CA 92697‑2715, USA. Electronic address: egratton22@gmail.com.
Fluor (United States) · USUniversity of California, Irvine · US

Funding

Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NIE, QING · 2007 to 2016
$25.1M
TRD4: Phasor analysisP41GM103540 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GRATTON, ENRICO · 2012 to 2020
$12.5M
NIGMS NIH HHS P41 GM103540NIGMS NIH HHS P50 GM076516
6 · The paper itself

Abstract

Fluorescence spectroscopy, coupled with microscopy, opens new frontiers for the study of dynamic processes with high spatio-temporal resolution. The application of phasor plots to FLIM and hyperspectral imaging demonstrate unprecedented capabilities to study complex photophysics at the subcellular level. Using these approaches we studied the effects of an H

Indexed as

Fluorescence2-NaphthylamineAnimalsCell MembraneFluorescent DyesHydrogen PeroxideLauratesMembrane FluidityMiceMicroscopy, FluorescenceNIH 3T3 CellsOxidants2-NaphthylamineFluorescent DyesHydrogen PeroxideLaurateslaurdanOxidantsDipolar relaxationHydrogen peroxideLAURDANMembrane dynamicsOxidative stressPhasor plots

Identifiers

PMID29885356
PMCPMC6175669
OpenAlexW2806682138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.