ArticleAllergy2018
17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use.
Open access · hybridAbstract readLetter
In one paragraph
Article in Allergy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Genome-wide association studies of exacerbations in children using long-acting beta2-agonists.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Pooled it
- A genome-wide association study of severe asthma exacerbations in Latino children and adolescents.The European respiratory journal · 2021Pooled it
- Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation.The European respiratory journal · 2024Article
- Severe Asthma and Biological Therapies: Now and the Future.Journal of clinical medicine · 2023Review
- Article
- Review
- Review
- Microbiome Research and Multi-Omics Integration for Personalized Medicine in Asthma.Journal of personalized medicine · 2021Review
- Genetic Determinants of Poor Response to Treatment in Severe Asthma.International journal of molecular sciences · 2021Review
- The Pathogenesis of Eosinophilic Asthma: A Positive Feedback Mechanism That Promotes Th2 Immune ResponseFrontiers in immunology · 2021Article
- Childhood asthma in the new omics era: challenges and perspectives.Current opinion in allergy and clinical immunology · 2020Review
- Omics for the future in asthma.Seminars in immunopathology · 2020Review
- Pharmacogenetics of Pediatric Asthma: Current Perspectives.Pharmacogenomics and personalized medicine · 2020Review
- The Effects of the Environment on Asthma Disease Activity.Immunology and allergy clinics of North America · 2019Review
- Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review.Clinical and translational allergy · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 20 institutions in 11 countries.
N FarzanDivision of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-3694-1086
S J VijverbergDivision of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-4579-4081
N Hernandez-PachecoResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
E H D BelDepartment of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
V BerceCentre for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.ORCID 0000-0002-0577-8925
K BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
H BisgaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4131-7592
E G BurchardDepartments of Medicine, Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.ORCID 0000-0001-7475-2035
G CaninoBehavioral Sciences Institute, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.
J C CeledónDivision of Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-1366-5936
F T ChewDepartment of Biological Sciences, National University of Singapore, Singapore, Singapore.ORCID 0000-0003-1337-5146
W C ChiangThe Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore, Singapore.
M M CloutierAsthma Center, Connecticut Children's Medical Center, University of Connecticut Health Center, Hartford, CT, USA.
E FornoDivision of Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6497-9885
B FrancisDepartment of Women's and Children's Health, University of Liverpool, Liverpool, UK.ORCID 0000-0002-2130-5976
D B HawcuttDepartment of Women's and Children's Health, University of Liverpool, Liverpool, UK.ORCID 0000-0002-8120-6507
E Herrera-LuisGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Tenerife, Spain.
M KabeschDepartment of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.ORCID 0000-0003-0697-1871
L KarimiDeptartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
E MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
S MukhopadhyayAcademic Department of Paediatrics, Brighton and Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK.
S K MeridInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-5974-7676
C N PalmerDivision of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
M Pino-YanesResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.ORCID 0000-0003-0332-437X
M PirmohamedDepartment of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.ORCID 0000-0002-7534-7266
U PotočnikCentre for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.ORCID 0000-0001-8688-174X
K RepnikCentre for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.ORCID 0000-0003-0801-1911
M SchieckDepartment of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.ORCID 0000-0001-5878-0546
A SevelstedCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-7117-2334
Y Y SioDepartment of Biological Sciences, National University of Singapore, Singapore, Singapore.
R L SmythInstitute of Child Health, University College London, London, UK.ORCID 0000-0003-1406-6142
P SoaresAcademic Department of Paediatrics, Brighton and Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK.ORCID 0000-0001-5033-9115
C SöderhällDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-8397-3080
K G TantisiraThe Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
R TavendaleDivision of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
S M TseDivision of Respiratory Medicine, Department of Pediatrics, Sainte-Justine University Hospital Center and University of Montreal, Montreal, QC, Canada.ORCID 0000-0002-0295-0064
S TurnerChild Health, University of Aberdeen, Aberdeen, UK.ORCID 0000-0001-8393-5060
K M VerhammeDeptartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-8162-4904
A-H Maitland-van der ZeeDivision of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-6261-9445
Karolinska Institutet · SEUniversidad de La Laguna · ESUniversity of Copenhagen · DKUniversity of Liverpool · GBUniversity of Maribor · SIUtrecht University · NLBrighton and Sussex Medical School · GBChildren's Hospital of Pittsburgh · USErasmus MC · NLNational University of Singapore · SGUniversity Hospital Regensburg · DEUniversity of Dundee · GBAmsterdam UMC Location University of Amsterdam · NLBrigham and Women's Hospital · USCentre Hospitalier Universitaire Sainte-Justine · CAConnecticut Children's Medical Center · USKK Women's and Children's Hospital · SGUniversity College London · GBUniversity of Aberdeen · GBUniversity of California, San Francisco · US
Funding
ERACoSysMed 1st Joint Transnational Call (SysPharmPedia)European Social Funds from the European Union (ESF)GSKInstituto de Salud Carlos III AC15/00015Instituto de Salud Carlos III ISCIIIMedical Research Council MR/L006758/1PACMAN cohortSpanish Ministry of Economy and Competitiveness RYC-2015-17205Stichting Astma bestrijdingU.S. National Institutes of HealthUtrecht Institute for Pharmaceutical Sciences
Abstract
PubMed holds no abstract for this paper.
Indexed as
Polymorphism, Single NucleotideAdministration, InhalationAdrenal Cortex HormonesAnti-Asthmatic AgentsAsthmaChromosomes, Human, Pair 17Disease ProgressionFemaleHumansMaleTreatment FailureAdrenal Cortex HormonesAnti-Asthmatic Agents
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.