Evidence map›Paper›PMID 29885152›Full record

ArticleJournal of studies on alcohol and drugs2018

Recent Self-Reported Cannabis Use Is Associated With the Biometrics of Delta-9-Tetrahydrocannabinol.

Matthew J Smith, Eva C Alden, Amy A Herrold, Andrea Roberts, Dan Stern, Joseph Jones, Allan Barnes, Kailyn P O'Connor, Marilyn A Huestis, Hans C Breiter

Abstract read
In one paragraph

Article in Journal of studies on alcohol and drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Co-Use of Some Substances Associated With Higher Doses in Adolescents: Findings From the Adolescent Brain Cognitive Development Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026
    Article
  2. Article
  3. Assessing Cannabis Use in People with Psychosis.Cannabis and cannabinoid research · 2024
    Review
  4. Psychoactive drugs and male fertility: impacts and mechanisms.Reproductive biology and endocrinology : RB&E · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthew J SmithSchool of Social Work, University of Michigan, Ann Arbor, Michigan.
Eva C AldenWarren Wright Adolescent Center, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Amy A HerroldWarren Wright Adolescent Center, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Andrea RobertsDepartment of Psychology, University of Michigan, Ann Arbor, Michigan.
Dan SternDepartment of Neuroscience, University of California-San Diego, La Jolla, California.
Joseph JonesUnited States Drug Testing Laboratories, Des Plaines, Illinois.
Allan BarnesChemistry and Drug Metabolism, National Institute on Drug Abuse, Rockville, Maryland.
Kailyn P O'ConnorWarren Wright Adolescent Center, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Marilyn A HuestisChemistry and Drug Metabolism, National Institute on Drug Abuse, Rockville, Maryland.
Hans C BreiterWarren Wright Adolescent Center, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Funding

Brain Targets for Alcohol Craving in Veterans with mTBI.IK2RX000949 · VA · EDWARD HINES JR VA HOSPITAL · PI HERROLD, AMY · 2015 to 2020
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RRD VA IK2 RX000949
6 · The paper itself

Abstract

objectiveResearch typically characterizes cannabis use by self-report of cannabis intake frequency. In an effort to better understand relationships between measures of cannabis use, we evaluated if Δ-9-tetrahydrocannabinol (THC) and metabolite concentrations (biometrics) were associated with a calibrated timeline followback (TLFB) assessment of cannabis use.

methodParticipants were 35 young adult male cannabis users who completed a calibrated TLFB measure of cannabis use over the past 30 days, including time of last use. The calibration required participants handling four plastic bags of a cannabis substitute (0.25, 0.5, 1.0, and 3.5 grams) to quantify cannabis consumed. Participants provided blood and urine samples for analysis of THC and metabolites, at two independent laboratories. Participants abstained from cannabis use on the day of sample collection. We tested Pearson correlations between the calibrated TLFB measures and cannabis biometrics.

resultsStrong correlations were seen between urine and blood biometrics (all r > .73, all p < .001). TLFB measures of times of use and grams of cannabis consumed were significantly related to each biometric, including urine 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) and blood THC, 11-hydroxy-THC (11-OH-THC), THCCOOH, THCCOOH-glucuronide (times of use: r > .48-.61, all p < .05; grams: r > .40-.49, all p < .05).

conclusionsThis study extends prior work to show TLFB methods significantly relate to an extended array of cannabis biometrics. The calibration of cannabis intake in grams was associated with each biometric, although the simple TLFB measure of times of use produced the strongest relationships with all five biometrics. These findings suggest that combined self-report and biometric data together convey the complexity of cannabis use, but allow that either the use of calibrated TLFB measures or biometrics may be sufficient for assessment of cannabis use in research.

Indexed as

AdolescentAdultDronabinolHumansMaleMarijuana SmokingSelf ReportSubstance Abuse DetectionYoung AdultDronabinol

Identifiers

PMID29885152
PMCPMC6005260

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.