Evidence map›Paper›PMID 29885070›Full record

ArticleMolecular microbiology2018

Expression and regulation of the Pseudomonas aeruginosa hibernation promoting factor.

Tatsuya Akiyama, Kerry S Williamson, Michael J Franklin

Open access · greenAbstract read
In one paragraph

Article in Molecular microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. TheInternational journal of molecular sciences · 2023
    Article
  6. Article
  7. Article
  8. Role of Hibernation Promoting Factor in Ribosomal Protein Stability duringInternational journal of molecular sciences · 2020
    Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tatsuya AkiyamaDepartment of Microbiology and Immunology, Montana State University, Bozeman, MT, USA.
Kerry S WilliamsonDepartment of Microbiology and Immunology, Montana State University, Bozeman, MT, USA.
Michael J FranklinDepartment of Microbiology and Immunology, Montana State University, Bozeman, MT, USA.
Montana State University · US

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Jeffrey Good · 2012 to 2026
$60.0M
Resuscitation of P. aeruginosa biofilm cells from dormancyR01AI113330 · NIAID · MONTANA STATE UNIVERSITY - BOZEMAN · PI FRANKLIN, MICHAEL J. · 2014 to 2018
$1.6M
Genetic and physiological analyses of P. aeruginosa dormancy factorsR21AI140163 · NIAID · MONTANA STATE UNIVERSITY - BOZEMAN · PI FRANKLIN, MICHAEL J. · 2018 to 2019
$391k
NIAID NIH HHS R01 AI113330NIAID NIH HHS R21 AI140163NIGMS NIH HHS P20 GM103474
6 · The paper itself

Abstract

Bacterial biofilms contain subpopulations of cells that are dormant and highly tolerant to antibiotics. While dormant, the bacteria must maintain the integrity of macromolecules required for resuscitation. Previously, we showed that hibernation promoting factor (HPF) is essential for protecting Pseudomonas aeruginosa from ribosomal loss during dormancy. In this study, we mapped the genetic components required for hpf expression. Using 5'-RACE and fluorescent protein reporter fusions, we show that hpf is expressed as part of the rpoN operon, but that hpf also has a second promoter (P

Indexed as

Bacterial ProteinsBiofilmsDNA, BacterialFluorescent DyesGene Expression Regulation, BacterialGene Knockout TechniquesMutationOperonPromoter Regions, GeneticPseudomonas aeruginosaRibosomal ProteinsRibosomesRNA, MessengerBacterial ProteinsDNA, BacterialFluorescent DyesRibosomal ProteinsRNA, Messenger

Identifiers

PMID29885070
PMCPMC7474867
OpenAlexW2805729328

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.