Evidence map›Paper›PMID 29885022›Full record

ArticleAngewandte Chemie (International ed. in English)2018

Stabilization of Aliphatic Phosphines by Auxiliary Phosphine Sulfides Offers Zeptomolar Affinity and Unprecedented Selectivity for Probing Biological Cu

M Thomas Morgan, Bo Yang, Shefali Harankhedkar, Arielle Nabatilan, Daisy Bourassa, Adam M McCallum, Fangxu Sun, Ronghu Wu, Craig R Forest, Christoph J Fahrni

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. A primer on copper biology in the brain.Neurobiology of disease · 2025
    Review
  3. Selective removal of copper from complex biological media with an agarose-immobilized high-affinity PSP ligand.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Selective Detection of CuAngewandte Chemie (International ed. in English) · 2021
    Article
  9. The requirement for cobalt in vitamin BBiochimica et biophysica acta. Molecular cell research · 2021
    Review
  10. Article
  11. The Glutathione/Metallothionein System Challenges the Design of Efficient OAngewandte Chemie (International ed. in English) · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Ratiometric two-photon microscopy reveals attomolar copper buffering in normal and Menkes mutant cells.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

M Thomas MorganSchool of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30332, USA.
Bo YangG. W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA, 30332, USA.
Shefali HarankhedkarSchool of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30332, USA.
Arielle NabatilanSchool of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30332, USA.
Daisy BourassaSchool of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30332, USA.
Adam M McCallumSchool of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30332, USA.
Fangxu SunSchool of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30332, USA.
Ronghu WuSchool of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30332, USA.
Craig R ForestG. W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA, 30332, USA.
Christoph J FahrniSchool of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30332, USA.ORCID 0000-0003-3731-7434
Georgia Institute of Technology · US

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7M
High-throughput robotic analysis of integrated neuronal phenotypesR01EY023173 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., FOREST, CRAIG · 2012 to 2016
$4.3M
Molecular Tools to Illuminate Copper Transport and HomeostasisR01GM067169 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI FAHRNI, CHRISTOPH J · 2004 to 2018
$3.5M
In-vivo circuit activity measurement at single cell, sub-threshold resolutionU01MH106027 · NIMH · GEORGIA INSTITUTE OF TECHNOLOGY · PI FOREST, CRAIG, STANLEY, GARRETT B. · 2014 to 2016
$1.5M
NEI NIH HHS R01 EY023173NIGMS NIH HHS R01 GM067169NIMH NIH HHS U01 MH106027NIMH NIH HHS U19 MH114830
6 · The paper itself

Abstract

Full elucidation of the functions and homeostatic pathways of biological copper requires tools that can selectively recognize and manipulate this trace nutrient within living cells and tissues, where it exists primarily as Cu

Indexed as

AnimalsChelating AgentsCopperHeLa CellsHumansMiceMice, Inbred C57BLMicroscopy, FluorescenceModels, MolecularMolecular StructurePhosphinesSulfidesChelating AgentsCopperPhosphinesSulfideschelationcopperelectrophysiologymetal homeostasissignaling

Identifiers

PMID29885022
PMCPMC6105516
OpenAlexW2806649422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.