Evidence map›Paper›PMID 29884977›Full record

ArticleEJNMMI research2018

Detection of neuroinflammation before selective neuronal loss appearance after mild focal ischemia using [

Natsumi Miyajima, Miwa Ito, Takemi Rokugawa, Hitoshi Iimori, Sotaro Momosaki, Shigeki Omachi, Eku Shimosegawa, Jun Hatazawa, Kohji Abe

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Comprehensive Analysis of the Effect of 20(Molecules (Basel, Switzerland) · 2022
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  6. Knockout of the P2YInternational journal of molecular sciences · 2022
    Article
  7. Ginkgolide B Protects Against Ischemic StrokeFrontiers in pharmacology · 2022
    Article
  8. Review
  9. TSPO imaging in animal models of brain diseases.European journal of nuclear medicine and molecular imaging · 2021
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Natsumi MiyajimaTranslational Research Unit, Biomarker R&D Department, Shionogi & Co., Ltd., Osaka, 5610825, Japan. natsumi.imamoto@shionogi.co.jp.ORCID http://orcid.org/0000-0002-6121-6994
Miwa ItoTranslational Research Unit, Biomarker R&D Department, Shionogi & Co., Ltd., Osaka, 5610825, Japan.
Takemi RokugawaTranslational Research Unit, Biomarker R&D Department, Shionogi & Co., Ltd., Osaka, 5610825, Japan.
Hitoshi IimoriDepartment of Applied Chemistry and Analysis, Research Laboratory for Development, Shionogi & Co., Ltd., Osaka, Japan.
Sotaro MomosakiTranslational Research Unit, Biomarker R&D Department, Shionogi & Co., Ltd., Osaka, 5610825, Japan.
Shigeki OmachiDepartment of medical affairs, Shionogi & Co., Ltd., Osaka, Japan.
Eku ShimosegawaDepartment of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Jun HatazawaDepartment of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Kohji AbeTranslational Research Unit, Biomarker R&D Department, Shionogi & Co., Ltd., Osaka, 5610825, Japan.
Shionogi (Japan) · JPThe University of Osaka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranslocator protein (TSPO) imaging can be used to detect neuroinflammation (including microglial activation) after acute cerebral infarction. However, longitudinal changes of TSPO binding after mild ischemia that induces selective neuronal loss (SNL) without acute infarction are not well understood. Here, we performed TSPO imaging with [

resultsMild focal ischemia was induced by middle cerebral artery occlusion (MCAO) for 20 min. In MCAO rats without acute infarction investigated by 2, 3, 5-triphenyltetrazolium chloride (TTC) staining, in vitro ARG revealed a significant increase of [

conclusions[

Indexed as

[18F]DPA-714 bindingMild ischemiaSelective neuronal lossTranslocator protein

Identifiers

PMID29884977
PMCPMC5993708
OpenAlexW2805150141

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.