ArticleScientific reports2018
Simple, low-cost fabrication of acrylic based droplet microfluidics and its use to generate DNA-coated particles.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Droplet based microfluidic and miniaturization at high-throughput level to screening heterologous secondary metabolites in microbes: A critical review.Biotechnology letters · 2025Review
- Fabrication of a Spiral Microfluidic Chip for the Mass Production of Lipid Nanoparticles Using Laser Engraving.Micromachines · 2025Article
- A study on the effect of the number of expansion units in a microfluidic chip on hyaluronidase-free oocyte denudation in mammals.Journal of electrical bioimpedance · 2025Article
- Development of a low-cost microfluidic chip for hyaluronidase-free oocyte denudation in mammals.Biotechnology notes (Amsterdam, Netherlands) · 2025Article
- An Alternative Micro-Milling Fabrication Process for Rapid and Low-Cost Microfluidics.Micromachines · 2024Article
- Design and development of a portable low-cost QCM-based system for liquid biosensing.Biomedical microdevices · 2024Article
- Fabrication of Spiral Low-Cost Microchannel with Trapezoidal Cross Section for Cell Separation Using a Grayscale Approach.Micromachines · 2023Article
- Toward a next-generation diagnostic tool: A review on emerging isothermal nucleic acid amplification techniques for the detection of SARS-CoV-2 and other infectious viruses.Analytica chimica acta · 2022Review
- From shaping to functionalization of micro-droplets and particles.Nanoscale advances · 2021Review
- Graphene oxide assisted light-up aptamer selection against Thioflavin T for label-free detection of microRNA.Scientific reports · 2021Article
- Rapid, multiplexed detection of biomolecules using electrically distinct hydrogel beads.Lab on a chip · 2020Article
- COMicromachines · 2019Article
- Asynchronous generation of oil droplets using a microfluidic flow focusing system.Scientific reports · 2019Article
- Polymer-Based Device Fabrication and Applications Using Direct Laser Writing Technology.Polymers · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogel microparticles were copolymerized with surface-immobilized DNA. Particles derived from a microfluidic device and particles derived from mechanical homogenization were compared. The hypothesis was tested that a controlled droplet generation mechanism would produce more homogeneous particles. Surprisingly, the DNA content of both particle types was similarly inhomogeneous. To make this test possible, a simple, low cost, and rapid method was developed to fabricate a microfluidic chip for droplet generation and in-line polymerization. This method used a low-cost laser cutter ($400) and direct heat bonding (no adhesives or intermediate layers). The flow focusing droplet generator produced droplets and hydrogel particles 10-200 μm in diameter.
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Registered trials
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