Evidence map›Paper›PMID 29884837›Full record

ArticleScientific reports2018

Genome-wide association study identifies genes associated with neuropathy in patients with head and neck cancer.

Cielito C Reyes-Gibby, Jian Wang, Sai-Ching J Yeung, Patrick Chaftari, Robert K Yu, Ehab Y Hanna, Sanjay Shete

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cielito C Reyes-GibbyDepartment of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. creyes@mdanderson.org.
Jian WangDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
Sai-Ching J YeungDepartment of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
Patrick ChaftariDepartment of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
Robert K YuDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
Ehab Y HannaDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
Sanjay SheteDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. sshete@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Molecular Epidemiology of Neuropathic Pain in Head and Neck CancerR01DE022891 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI REYES-GIBBY, CIELITO C, SHETE, SANJAY · 2012 to 2016
$3.0M
Innovative Multidisciplinary Education: The Statistical Genetics of AddictionR25DA026120 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHANG, SHINE, SHETE, SANJAY · 2010 to 2014
$1.5M
Composition and temporal changes of the oral microbiome in head and neck cancer patients at high risk for oral mucositisR21DE026837 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI REYES-GIBBY, CIELITO C, SHETE, SANJAY · 2018 to 2019
$453k
Method to analyze X-chromosomal genetic dataR03CA192197 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WANG, JIAN · 2015 to 2016
$160k
NCI NIH HHS P30 CA016672NCI NIH HHS R03 CA192197NIDA NIH HHS R25 DA026120NIDCR NIH HHS R01 DE022891NIDCR NIH HHS R21 DE026837
6 · The paper itself

Abstract

Neuropathic pain (NP), defined as pain initiated or caused by a primary lesion or dysfunction in the nervous system, is a debilitating chronic pain condition often resulting from cancer treatment. Among cancer patients, neuropathy during cancer treatment is a predisposing event for NP. To identify genetic variants influencing the development of NP, we conducted a genome-wide association study in 1,043 patients with squamous cell carcinoma of the head and neck, based on 714,494 tagging single-nucleotide polymorphisms (SNPs) (130 cases, 913 controls). About 12.5% of the patients, who previously had cancer treatment, had neuropathy-associated diagnoses, as defined using the ICD-9/ICD-10 codes. We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10

Indexed as

Polymorphism, Single NucleotideAgedCarcinoma, Squamous CellFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHead and Neck NeoplasmsHumansKininogensMaleMiddle AgedNerve Tissue ProteinsNeuralgiaNuclear Receptor Subfamily 1, Group F, Member 1Sorting NexinsKininogensKNG1 protein, humanNerve Tissue ProteinsNuclear Receptor Subfamily 1, Group F, Member 1Purkinje cell protein L7RORA protein, humanSNX8 protein, humanSorting Nexins

Identifiers

PMID29884837
PMCPMC5993794
OpenAlexW2806228790

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.