ArticleNature communications2018
Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Revealing the Mechanisms of Alzheimer's, Parkinson's and Huntington's Diseases Through Invertebrate Models.Biology · 2026Review
- Multisensory pathogen detection drives rapid escape and shapes host-microbe interactions in Drosophila larvae.PLoS pathogens · 2026Article
- Connectivity of serotonin neurons reveals a constrained inhibitory subnetwork within the olfactory system.Journal of neurophysiology · 2026Article
- Nonlinear high-activity neuronal excitation enhances odor discrimination.Current biology : CB · 2025Article
- Article
- Transgenic line for characterizing GABA-receptor expression to study the neural basis of olfaction in the yellow-fever mosquito.Frontiers in physiology · 2024Article
- A conditional strategy for cell-type-specific labeling of endogenous excitatory synapses inCell reports methods · 2023Article
- Stability of olfactory behavior syndromes in the Drosophila larva.Scientific reports · 2023Article
- Synaptic Development in Diverse Olfactory Neuron Classes Uses Distinct Temporal and Activity-Related Programs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Review
- Review
- Mating-driven variability in olfactory local interneuron wiring.Science advances · 2022Article
- Article
- Adaptive temporal processing of odor stimuli.Cell and tissue research · 2021Review
- Interhemispheric asymmetry of c-Fos expression in glomeruli and the olfactory tubercle following repeated odor stimulation.FEBS open bio · 2020Article
- Muscarinic Modulation of Antennal Lobe GABAergic Local Neurons Shapes Odor Coding and Behavior.Cell reports · 2019Article
- Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system.Nature communications · 2019Article
- Strength in diversity: functional diversity among olfactory neurons of the same type.Journal of bioenergetics and biomembranes · 2019Review
- Interneuron Diversity: Toward a Better Understanding of Interneuron Development In the Olfactory System.Journal of experimental neuroscience · 2019Review
- A resource for theeLife · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
Drosophila olfactory local interneurons (LNs) in the antennal lobe are highly diverse and variable. How and when distinct types of LNs emerge, differentiate, and integrate into the olfactory circuit is unknown. Through systematic developmental analyses, we found that LNs are recruited to the adult olfactory circuit in three groups. Group 1 LNs are residual larval LNs. Group 2 are adult-specific LNs that emerge before cognate sensory and projection neurons establish synaptic specificity, and Group 3 LNs emerge after synaptic specificity is established. Group 1 larval LNs are selectively reintegrated into the adult circuit through pruning and re-extension of processes to distinct regions of the antennal lobe, while others die during metamorphosis. Precise temporal control of this pruning and cell death shapes the global organization of the adult antennal lobe. Our findings provide a road map to understand how LNs develop and contribute to constructing the olfactory circuit.
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