Evidence map›Paper›PMID 29884768›Full record

ArticleThe Journal of biological chemistry2018

Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.

Jesalyn A Bolduc, Kimberly J Nelson, Alexina C Haynes, Jingyun Lee, Julie A Reisz, Aaron H Graff, Jill E Clodfelter, Derek Parsonage, Leslie B Poole, Cristina M Furdui and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Overoxidation and Oligomerization ofPathogens (Basel, Switzerland) · 2023
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Prdx1 Interacts with ASK1 upon Exposure to HAntioxidants (Basel, Switzerland) · 2021
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. PeerJ · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Jesalyn A BolducFrom the Center for Structural Biology, Department of Biochemistry.
Kimberly J NelsonFrom the Center for Structural Biology, Department of Biochemistry.
Alexina C HaynesFrom the Center for Structural Biology, Department of Biochemistry.
Jingyun LeeWake Forest Baptist Comprehensive Cancer Center, and.
Julie A ReiszSection on Molecular Medicine, Department of Internal Medicine.ORCID 0000-0002-7296-4963
Aaron H GraffFrom the Center for Structural Biology, Department of Biochemistry.
Jill E ClodfelterFrom the Center for Structural Biology, Department of Biochemistry.
Derek ParsonageFrom the Center for Structural Biology, Department of Biochemistry.
Leslie B PooleFrom the Center for Structural Biology, Department of Biochemistry.
Cristina M FurduiSection on Molecular Medicine, Department of Internal Medicine.
W Todd LowtherFrom the Center for Structural Biology, Department of Biochemistry, tlowther@wakehealth.edu.
Joint Center for Structural Genomics · USAtrium Health Wake Forest Baptist · USInstitute of Molecular Medicine · IN

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox SystemsR01GM050389 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI POOLE, LESLIE B · 1994 to 2013
$4.8M
Structures &Redox Chemistry in Sulfinic Acid ReductionR01GM072866 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LOWTHER, W TODD · 2005 to 2014
$2.6M
Mechanisms and Regulation of PeroxiredoxinsR01GM119227 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI POOLE, LESLIE B · 2016 to 2019
$1.4M
NCI NIH HHS P30 CA012197NIGMS NIH HHS R01 GM050389NIGMS NIH HHS R01 GM072866NIGMS NIH HHS R01 GM119227
6 · The paper itself

Abstract

2-Cys peroxiredoxins (Prxs) modulate hydrogen peroxide (H

Indexed as

Amino Acid MotifsAmino Acid SequenceCrystallography, X-RayCysteineHumansHydrogen PeroxideModels, MolecularOxidation-ReductionPeroxiredoxinsCysteineHydrogen PeroxidePeroxiredoxinsPRDX1 protein, humanPRDX2 protein, humancell signalingCys sulfinic acidenzyme kineticsoxidation-reduction (redox)peroxiredoxinprotein oxidationredox biologystructural biologyX-ray crystallography

Identifiers

PMID29884768
PMCPMC6066324
OpenAlexW2807432808

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.