ArticleThe Journal of biological chemistry2018
AKT keeps the beat in CLOCK's circadian rhythm.
Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Phosphorylation and Circadian Molecular Timing.Frontiers in physiology · 2020Pooled it
- Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock.NPJ precision oncology · 2024Review
- Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day.BMJ open sport & exercise medicine · 2021Article
- Time-of-day dependent effects of contractile activity on the phase of the skeletal muscle clock.The Journal of physiology · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian clock plays a critical role in physiology and medicine by cyclically regulating the expression of numerous genes. The core components of the clock are thought to be controlled by several regulatory mechanisms, including post-translational modifications, but the full extent of this regulation is not known. In this issue, Sessa and co-workers demonstrate that the transcription factor CLOCK is a direct substrate of the kinase AKT. This phosphorylation controls the nuclear-cytosolic translocation of CLOCK and thus its ability to regulate circadian gene expression in peripheral tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.