Evidence map›Paper›PMID 29884747›Full record

ArticleGenetics2018

Maintenance of Proper Germline Stem Cell Number Requires Adipocyte Collagen in Adult

Lesley N Weaver, Daniela Drummond-Barbosa

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Basement membrane structure and function: Relating biology to mechanics.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  2. Article
  3. Biomolecules · 2025
    Review
  4. Adipocyte-DerivedBiomolecules · 2025
    Article
  5. Review
  6. Article
  7. Finishing the egg.Genetics · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Cyromazine affects the ovarian germ cells ofFrontiers in physiology · 2022
    Article
  12. Review
  13. Article
  14. Collagen IV differentially regulates planarian stem cell potency and lineage progression.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Regulation of Drosophila germline stem cells.Current opinion in cell biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lesley N WeaverDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205.ORCID 0000-0002-3120-8301
Daniela Drummond-BarbosaDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205 dbarbosa@jhu.edu.ORCID 0000-0002-7330-457X
Johns Hopkins University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI KEVIN R COOK · 2014 to 2026
$13.5M
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
Nutrient Sensing in Adipocytes and the Control of Oogenesis in DrosophilaR01GM069875 · NIGMS · VANDERBILT UNIVERSITY · PI DRUMMOND-BARBOSA, DANIELA · 2005 to 2020
$5.2M
Understanding how Nuclear Receptor Signaling in Adipocytes Influences Tissue Stem Cell LineagesF32GM119199 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI WEAVER, LESLEY NICOLE · 2016 to 2017
$116k
NCI NIH HHS T32 CA009110NIGMS NIH HHS F32 GM119199NIGMS NIH HHS R01 GM069875NIH HHS P40 OD018537
6 · The paper itself

Abstract

Stem cells reside in specialized niches and are regulated by a variety of physiological inputs. Adipocytes influence whole-body physiology and stem cell lineages; however, the molecular mechanisms linking adipocytes to stem cells are poorly understood. Here, we report that collagen IV produced in adipocytes is transported to the ovary to maintain proper germline stem cell (GSC) number in adult

Indexed as

AdipocytesAnimalsCadherinsCell CountCell LineageCells, CulturedCollagen Type IVDrosophilaDrosophila ProteinsExtracellular Matrix ProteinsFemaleFocal Adhesion Kinase 1Integrin beta ChainsOvaryProtein TransportSignal TransductionCadherinsCOL4A1 protein, DrosophilaCollagen Type IVDrosophila ProteinsExtracellular Matrix ProteinsFocal Adhesion Kinase 1Integrin beta Chainsshg protein, Drosophilaadipocytescollagen IVDrosophilagermline stem cellsoogenesis

Identifiers

PMID29884747
PMCPMC6063239
OpenAlexW2805131761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.