Evidence map›Paper›PMID 29884698›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Leukocyte-Associated Ig-like Receptor 1 Inhibits T

Vrushali V Agashe, Ewa Jankowska-Gan, Melissa Keller, Jeremy A Sullivan, Lynn D Haynes, John F Kernien, Jose R Torrealba, Drew Roenneburg, Melanie Dart, Marco Colonna and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Vrushali V AgasheDivision of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792.ORCID 0000-0001-8800-5946
Ewa Jankowska-GanDivision of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792.
Melissa KellerMichigan State University, East Lansing, MI 48824.ORCID 0000-0002-9539-9768
Jeremy A SullivanDivision of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792.
Lynn D HaynesDivision of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792.ORCID 0000-0002-3971-8429
John F KernienDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-4424-7713
Jose R TorrealbaDivision of Renal Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Drew RoenneburgDivision of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792.
Melanie DartPromega Corporation, Madison, WI 53711.ORCID 0000-0001-5429-3695
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110; and.
David S WilkesUniversity of Virginia School of Medicine, Charlottesville, VA 22908.
William J BurlinghamDivision of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792; burlingham@surgery.wisc.edu.
University of Wisconsin–Madison · USMichigan State University · USPromega (United States) · USThe University of Texas Southwestern Medical Center · USUniversity of Virginia · USWashington University in St. Louis · US

Funding

Transgenic Mouse CoreP01AI084853 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI WILKES, DAVID S · 2010 to 2014
$7.7M
The Role of Complement Inhibition in Expanded Criteria Kidney TransplantationR01AI110617 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KAUFMAN, DIXON B · 2015 to 2019
$4.1M
Natural vs. Pathogenic Th17 responses to col Va1, Ka1tubulin and vimentinR01AI119140 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SULLIVAN, JEREMY A · 2016 to 2020
$1.9M
Exosome-mediated Tolerance in combined Kidney and Stem Cell TransplantationR21AI147157 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI FOLEY, DAVID PAUL · 2019 to 2020
$426k
Detection of IL35+ Exosomes as a Marker for Peripheral ToleranceR03AI146688 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI FOLEY, DAVID PAUL · 2020 to 2021
$155k
NIAID NIH HHS P01 AI084853NIAID NIH HHS R01 AI110617NIAID NIH HHS R01 AI119140NIAID NIH HHS R03 AI146688NIAID NIH HHS R21 AI147157
6 · The paper itself

Abstract

Leukocyte-associated Ig-like receptor 1 (LAIR1) is an ITIM-bearing collagen receptor expressed by leukocytes and is implicated in immune suppression. However, using a divalent soluble LAIR1/Fc recombinant protein to block interaction of cell surface LAIR1 with matrix collagen, we found that whereas T

Indexed as

AnimalsAutoantigensCells, CulturedCollagenGraft RejectionHumansImmunity, CellularImmunomodulationInterleukin-17MiceMice, Inbred C57BLMice, KnockoutMonocytesOrgan TransplantationProtein BindingReceptors, ImmunologicAutoantigensCollagenInterleukin-17leukocyte-associated immunoglobulin-like receptor 1Receptors, Immunologic

Identifiers

PMID29884698
PMCPMC7039397
OpenAlexW2805509356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.