Evidence map›Paper›PMID 29884696›Full record

ArticleBMJ open2018

Systematic literature review of methodologies and data sources of existing economic models across the full spectrum of Alzheimer's disease and dementia from apparently healthy through disease progression to end of life care: a systematic review protocol.

Maria Karagiannidou, Raphael Wittenberg, Filipa Isabel Trigo Landeiro, A-La Park, Andra Fry, Martin Knapp, Alastair M Gray, Antje Tockhorn-Heidenreich, Amparo Yovanna Castro Sanchez, Isaac Ghinai and 4 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Mapping Evidence on Management of Cervical Cancer in Sub-Saharan Africa: Scoping Review.International journal of environmental research and public health · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Maria KaragiannidouPersonal Social Services Research Unit, Department of Health Policy, London School of Economics and Political Science, London, UK.
Raphael WittenbergPersonal Social Services Research Unit, Department of Health Policy, London School of Economics and Political Science, London, UK.
Filipa Isabel Trigo LandeiroNuffield Department of Population Health, Health Economics Research Centre, Oxford, UK.
A-La ParkPersonal Social Services Research Unit, Department of Health Policy, London School of Economics and Political Science, London, UK.
Andra FryDepartment of Health Policy, London School of Economics and Political Science, London, UK.
Martin KnappPersonal Social Services Research Unit, Department of Health Policy, London School of Economics and Political Science, London, UK.
Alastair M GrayNuffield Department of Population Health, Health Economics Research Centre, Oxford, UK.ORCID 0000-0003-0239-7278
Antje Tockhorn-HeidenreichGPORWE International, Eli Lilly Limited, Erl Wood Manor, Windlesham, UK.
Amparo Yovanna Castro SanchezF. Hoffmann-La Roche Ltd, MORSE Health Technology Assessment Group, Basel, Switzerland.
Isaac GhinaiNuffield Department of Population Health, Health Economics Research Centre, Oxford, UK.
Ron HandelsDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neurosciences, Maastricht University, Maastricht, The Netherlands.
Pascal LecomteGlobal Head Health Economic Modelling and Methodology, Basel, Switzerland.
Jane WolstenholmeNuffield Department of Population Health, Health Economics Research Centre, Oxford, UK.
ROADMAP Group
London School of Economics and Political Science · GBEli Lilly (United Kingdom) · GBKarolinska Institutet · SERoche (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDementia is one of the greatest health challenges the world will face in the coming decades, as it is one of the principal causes of disability and dependency among older people. Economic modelling is used widely across many health conditions to inform decisions on health and social care policy and practice. The aim of this literature review is to systematically identify, review and critically evaluate existing health economics models in dementia. We included the full spectrum of dementia, including Alzheimer's disease (AD), from preclinical stages through to severe dementia and end of life. This review forms part of the Real world Outcomes across the Alzheimer's Disease spectrum for better care: multimodal data Access Platform (ROADMAP) project. METHODS AND ANALYSIS: Electronic searches were conducted in Medical Literature Analysis and Retrieval System Online, Excerpta Medica dataBASE, Economic Literature Database, NHS Economic Evaluation Database, Cochrane Central Register of Controlled Trials, Cost-Effectiveness Analysis Registry, Research Papers in Economics, Database of Abstracts of Reviews of Effectiveness, Science Citation Index, Turning Research Into Practice and Open Grey for studies published between January 2000 and the end of June 2017. Two reviewers will independently assess each study against predefined eligibility criteria. A third reviewer will resolve any disagreement. Data will be extracted using a predefined data extraction form following best practice. Study quality will be assessed using the Phillips checklist for decision analytic modelling. A narrative synthesis will be used. ETHICS AND DISSEMINATION: The results will be made available in a scientific peer-reviewed journal paper, will be presented at relevant conferences and will also be made available through the ROADMAP project. PROSPERO REGISTRATION NUMBER: CRD42017073874.

Indexed as

Disease ProgressionModels, EconomicSystematic Reviews as TopicAlzheimer DiseaseCost-Benefit AnalysisDementiaHumansInformation Storage and RetrievalResearch DesignTerminal CareAlzheimer’s diseasedementiadisease progressioneconomic modelsystematic review

Identifiers

PMID29884696
PMCPMC6009454
OpenAlexW2806229857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.