ArticleJMIR research protocols2018
Human Papillomavirus and Oropharyngeal Cancer Among Indigenous Australians: Protocol for a Prevalence Study of Oral-Related Human Papillomavirus and Cost-Effectiveness of Prevention.
Article in JMIR research protocols, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 25 citations in OpenAlex.
- Population-based utility scores for HPV infection and cervical squamous cell carcinoma among Australian Indigenous women.PloS one · 2021Trial
- Article
- Knowledge and Awareness of HPV, the HPV Vaccine and Cancer-Related HPV Types among Indigenous Australians.International journal of environmental research and public health · 2024Article
- Association of Human Papillomavirus Infection with Tonsillar Cancers: A Systematic Review.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- The Indigenous Australian Human Papillomavirus (HPV) Cohort Study 2, Continuation for 5 to 10 Years: Protocol for a Longitudinal Study.JMIR research protocols · 2023Article
- Article
- Population-based utility scores for HPV infection and oropharyngeal squamous cell carcinoma among Indigenous Australians.BMC public health · 2021Article
- Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort.BMJ open · 2021Article
- Psychometric properties of the EQ-5D-5L for aboriginal Australians: a multi-method study.Health and quality of life outcomes · 2021Article
- Poor self-rated oral health associated with poorer general health among Indigenous Australians.BMC public health · 2021Article
- The impact of interpersonal racism on oral health related quality of life among Indigenous South Australians: a cross-sectional study.BMC oral health · 2021Article
- The role of the oral microbiota in chronic non-communicable disease and its relevance to the Indigenous health gap in Australia.BMC oral health · 2020Review
- 'There's a Wall There-And That Wall Is Higher from Our Side': Drawing on Qualitative Interviews to Improve Indigenous Australians' Experiences of Dental Health Services.International journal of environmental research and public health · 2020Article
- Prevalence of Oral Human Papillomavirus Infection Among Australian Indigenous Adults.JAMA network open · 2020Article
- Engaging with Indigenous Australian communities for a human papilloma virus and oropharyngeal cancer project; use of the CONSIDER statement.BMC medical research methodology · 2020Article
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Authors and funding
16 authors at 9 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOropharyngeal cancer is an important, understudied cancer affecting Aboriginal and Torres Strait Islander Australians. The human papillomavirus (HPV) is a significant risk factor for oropharyngeal cancer. Current generation HPV vaccines are effective against the 2 most common types of high-risk HPVs in cancer (hrHPVs 16/18).
objectivesThis study aims (1) to yield population estimates of oncogenic genotypes of HPV in the mouth and oropharynx of defined Aboriginal and Torres Strait Islander populations; (2) to estimate the proportion of oropharyngeal cancer attributable to HPV among these Australian citizens; (3) to estimate the impact of HPV vaccination as currently implemented on rates of oropharyngeal cancer among Aboriginal and Torres Strait Islander Australians; and (4) taking into account impact on oropharyngeal as well as cervical cancer, to evaluate efficacy and cost-effectiveness of targeted extended HPV vaccination to older ages, among our study population.
methodsOur study design and operation is straightforward, with minimal impost on participants. It involves testing for carriage of hrHPV in the mouth and oropharynx among 1000 Aboriginal South Australians by simple saliva collection and with follow-up at 12 and 24 months, collection of sexual history at baseline, collection of information for estimating health state (quality-of-life) utilities at baseline, genotyping of viruses, predictive outcome and cost-effectiveness modeling, data interpretation and development of vaccination, and follow-up management strategies driven by the Aboriginal community.
resultsParticipant recruitment for this study commenced in February 2018 and enrollment is ongoing. The first results are expected to be submitted for publication in 2019.
conclusionsThe project will have a number of important outcomes. Synthesis of evidence will enable generation of estimates of the burden of oropharyngeal cancer among Aboriginal and Torres Strait Islander Australians and indicate the likely effectiveness and cost-effectiveness of prevention. This will be important for health services planning, and for Aboriginal health worker and patient education. The results will also point to important areas where research efforts should be focused to improve outcomes in Aboriginal and Torres Strait Islander Australians with oropharyngeal cancer. There will be a strong focus on community engagement and accounting for the preferences of individuals and the community in control of HPV-related cancers. The project has international relevance in that it will be the first to systematically evaluate prevention of both cervical and oropharyngeal cancer in a high-risk Indigenous population taking into account all population, testing, and surveillance options. REGISTERED REPORT IDENTIFIER: RR1-10.2196/10503.
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