Evidence map›Paper›PMID 29884460›Full record

ArticleImmunity2018

Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis.

Carlson Tsui, Nuria Martinez-Martin, Mauro Gaya, Paula Maldonado, Miriam Llorian, Nathalie M Legrave, Merja Rossi, James I MacRae, Angus J Cameron, Peter J Parker and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.

  1. Pooled it
  2. A guide to B cell metabolism.Nature reviews. Immunology · 2026
    Review
  3. RNA binding proteinScience advances · 2026
    Article
  4. Review
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  19. Observational
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Carlson TsuiLymphocyte Interaction Laboratory, The Francis Crick Institute, London NW1 1AT, UK. Electronic address: carlson.tsui@crick.ac.uk.
Nuria Martinez-MartinLymphocyte Interaction Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Mauro GayaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Paula MaldonadoLymphocyte Interaction Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Miriam LlorianBioinformatics, The Francis Crick Institute, London NW1 1AT, UK.
Nathalie M LegraveMetabolomics, The Francis Crick Institute, London NW1 1AT, UK.
Merja RossiMetabolomics, The Francis Crick Institute, London NW1 1AT, UK.
James I MacRaeMetabolomics, The Francis Crick Institute, London NW1 1AT, UK.
Angus J CameronBarts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Peter J ParkerProtein phosphorylation Laboratory, The Francis Crick Institute, London NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, King's College, London SE1 1UL, UK.
Michael LeitgesBiotechnology Centre of Oslo, University of Oslo, 0349 Oslo, Norway.
Andreas BruckbauerLymphocyte Interaction Laboratory, The Francis Crick Institute, London NW1 1AT, UK; FILM, Imperial College London, London SW7 2BB, UK.
Facundo D BatistaLymphocyte Interaction Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address: fbatista1@mgh.harvard.edu.
The Francis Crick Institute · GBKing's College London · GBQueen Mary University of London · GBRagon Institute of MGH, MIT and Harvard · USUniversity of Oslo · NO

Funding

Support Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BAROUCH, DAN H. · 2012 to 2018
$131.5M
The Role of Canonical and Non-canonical Autophagy in B Cell ImmunityR01AI135052 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BATISTA, FACUNDO DAMIAN · 2018 to 2022
$2.3M
Cancer Research UK 15683Cancer Research UK FC001035Cancer Research UK FC001136Medical Research CouncilNIAID NIH HHS R01 AI135052NIAID NIH HHS UM1 AI100663Wellcome Trust FC001136
6 · The paper itself

Abstract

PKCβ-null (Prkcb

Indexed as

AnimalsB-LymphocytesCell DifferentiationHemeLymphocyte ActivationMiceMice, KnockoutMitochondriaPlasma CellsProtein Kinase C betaHemeProtein Kinase C betaB cell activationB cellsBCR signalingmetabolic reprogramming

Identifiers

PMID29884460
PMCPMC6015119
OpenAlexW2806609121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.