Evidence map›Paper›PMID 29884459›Full record

ArticleImmunity2018

Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM

Kathryn A Pape, Robert W Maul, Thamotharampillai Dileepan, Amanda Schmidt Paustian, Patricia J Gearhart, Marc K Jenkins

Open access · bronzeAbstract read
In one paragraph

Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 75 citations in OpenAlex.

  1. Trial
  2. Article
  3. The multilayered identity of B cell memory.Cellular & molecular immunology · 2026
    Review
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  5. Article
  6. Article
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  9. B Cell Receptor Transgenic Mice as Tools to Study Memory B Cells.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kathryn A PapeDepartment of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Robert W MaulLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 USA.
Thamotharampillai DileepanDepartment of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Amanda Schmidt PaustianAbbVie Pharmaceuticals, North Chicago, IL 60064, USA.
Patricia J GearhartLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 USA.
Marc K JenkinsDepartment of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: jenki002@umn.edu.
University of Minnesota Medical Center · USNational Institutes of Health · USAbbVie (United States) · US

Funding

Protein Interactions in Antibody DiversityZIAAG000732 · NIA · NATIONAL INSTITUTE ON AGING · PI GEARHART, PATRICIA J · 2009 to 2025
$10.7M
TRACKING CD4+ MEMORY T CELLS IN VIVOR01AI039614 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JENKINS, MARC KEVIN · 1996 to 2023
$8.7M
COSTIMULATORY SIGNALS IN CD4+ T-CELL ACTIVATIONR01AI027998 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JENKINS, MARC KEVIN · 1989 to 2022
$4.5M
Costimulatory Signals in CD4+ T Cell ActivationR37AI027998 · NIAID · UNIVERSITY OF MINNESOTA · PI JENKINS, MARC KEVIN · 2008 to 2017
$3.7M
Intramural NIH HHS ZIA AG000732NIAID NIH HHS R01 AI027998NIAID NIH HHS R01 AI039614NIAID NIH HHS R37 AI027998
6 · The paper itself

Abstract

Although immune memory often lasts for life, this is not the case for certain vaccines in some individuals. We sought a mechanism for this phenomenon by studying B cell responses to phycoerythrin (PE). PE immunization of mouse strains with Igh

Indexed as

AnimalsB-LymphocytesGenes, ImmunoglobulinImmunoglobulin GImmunoglobulin Heavy ChainsImmunoglobulin MImmunoglobulin Variable RegionImmunologic MemoryMiceReceptors, Antigen, B-CellImmunoglobulin GImmunoglobulin Heavy ChainsImmunoglobulin MImmunoglobulin Variable RegionReceptors, Antigen, B-Cellmemory B cellnaive B cellrepertoireV(H)

Identifiers

PMID29884459
PMCPMC6052797
OpenAlexW2807525444

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.