Evidence map›Paper›PMID 29884300›Full record

ArticlePlacenta2018

Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta.

Naveen K Neradugomma, Kaitlyn Drafton, Diana R O'Day, Michael Z Liao, Lyrialle W Han, Ian A Glass, Qingcheng Mao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Naveen K NeradugommaDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, United States. Electronic address: naveennk@uw.edu.
Kaitlyn DraftonDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, United States.
Diana R O'DayDepartment of Pediatrics, School of Medicine, University of Washington, Seattle, WA 98195, United States.
Michael Z LiaoDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, United States.
Lyrialle W HanDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, United States.
Ian A GlassDepartment of Pediatrics, School of Medicine, University of Washington, Seattle, WA 98195, United States.
Qingcheng MaoDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, United States. Electronic address: qmao@uw.edu.
University of Washington · US

Funding

Understanding Fetal Exposure to Cannabinoids Through In Vitro and In Vivo StudiesP01DA032507 · NIDA · UNIVERSITY OF WASHINGTON · PI UNADKAT, JASHVANT D · 2013 to 2023
$12.4M
NIDA NIH HHS P01 DA032507
6 · The paper itself

Abstract

Marijuana is one of the most abused drugs among pregnant women leading to maternal and fetal abnormalities. Cannabinoids are the active ingredients of marijuana, which interact with cannabinoid receptors such as CNR1 and CNR2 to activate cellular signaling pathways. Human endometrium and placenta are known to express CNR1 and CNR2 and can respond to cannabinoid signaling. In this study, we show that marijuana use significantly increases mRNA or protein expression of CNR1 and CNR2 in human endometrium from the first and early second trimester pregnancies, with minor effects on placental expression of CNRs.

Indexed as

AdolescentAdultAlcohol DrinkingCase-Control StudiesEndometriumFemaleHumansMarijuana UsePlacentaPregnancyPregnancy Trimester, FirstPregnancy Trimester, SecondReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2RNA, MessengerSignal TransductionCNR1 protein, humanCNR2 protein, humanReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2RNA, MessengerCannabinoidCannabinoid receptorMarijuanaPlacentaUterine endometrium

Identifiers

PMID29884300
PMCPMC5995327
OpenAlexW2801888474

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.