Evidence map›Paper›PMID 29884281›Full record

ReviewBiological psychiatry. Cognitive neuroscience and neuroimaging2018

Interoception and Mental Health: A Roadmap.

Sahib S Khalsa, Ralph Adolphs, Oliver G Cameron, Hugo D Critchley, Paul W Davenport, Justin S Feinstein, Jamie D Feusner, Sarah N Garfinkel, Richard D Lane, Wolf E Mehling and 15 more

8 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 710 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
710citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05766852 nacompletednot on this mapstarted 2023, after this paper: background citation

Potential Benefits of the Somatic Psychoeducational Intervention for Improving the Health and Wellness of Healthcare Providers

TypeinterventionalSponsorUniversity of FloridaRan2023 to 2024Enrolled31ConditionsWork Related StressArmsSomatic Psychoeducational Intervention
NCT05907538 unknown statusnot on this mapstarted 2022, after this paper: background citation

Interoception in Patients With Medically Unexplained Symptoms

TypeobservationalSponsorHasselt UniversityRan2022 to 2024Enrolled84ConditionsFibromyalgia, Burnout, PsychologicalArmsInteroceptive accuracy measurement, Interoceptive sensibility measurement, Interoceptive awareness measurement
NCT05907590 unknown statusnot on this mapstarted 2022, after this paper: background citation

Proprioception and Interoception in Patients With Fibromyalgia

TypeobservationalSponsorHasselt UniversityRan2022 to 2023Enrolled52ConditionsFibromyalgiaArmsInteroceptive accuracy measurement, Interoceptive sensibility measurement, Interoceptive awareness measurement, Proprioceptive accuracy measurement during postural control, Proprioceptive accuracy measurement of the neck
NCT06285864 nacompletednot on this mapstarted 2024, after this paper: background citation

Sense to Act: Pilot Randomized-controlled Trial of an Interoceptive Sensibility Intervention for Musculoskeletal Pain

TypeinterventionalSponsorIscte-University Institute of LisbonRan2024 to 2024Enrolled71ConditionsMusculoskeletal Pain, Chronic PainArmsInteroception-based intervention
NCT06695715 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Heart Rate Variability Biofeedback, Interoceptive Training, and Mindfulness on Stress Reduction in the University of Seville Academic Community (Faculty, Administrative Staff, and Students)

TypeinterventionalSponsorUniversity of SevilleRan2025 to 2026Enrolled120ConditionsStress, AnxietyArmsMindfulness Training Program, HRV Biofeedback, Interoception Training
NCT07325110 recruitingnot on this mapstarted 2026, after this paper: background citation

Interoceptive Awareness and Function in Adolescents With Chronic Pain

TypeobservationalSponsorConnecticut Children's Medical CenterRan2026 to 2028Enrolled49ConditionsChronic Pain, Chronic Pain Syndrome, Pain, ChronicArmsOccupational Therapy
NCT07696234 completednot on this mapstarted 2026, after this paper: background citation

Examining the Relationships Between Interoceptive Awareness, Perceived Stress, and Physical Performance Indicators: The Moderator Role of Gender and Sport Type

TypeobservationalSponsorInonu UniversityRan2026 to 2026Enrolled85ConditionsInteroception, Perceived Stress, Anxiety, Sleep QualityArmsPsychological and Physical Performance Assessment Battery
NCT07757815 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Multimodal Biomarkers and Robot-Guided Precision TMS for Early Detection and Treatment of Postpartum Depression

TypeinterventionalSponsorUniversity of MacauRan2026 to 2031Enrolled290ConditionsDepression, PostpartumArmsRepetitive Transcranial Magnetic Stimulation (rTMS)
3 · Its place in the literature

Who cites it

710 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  9. Changes in body awareness in yoga interventions: A systematic review.Complementary therapies in clinical practice · 2025
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650 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Sahib S KhalsaLaureate Institute for Brain Research, University of Tulsa, Tulsa, Oklahoma; Oxley College of Health Sciences, University of Tulsa, Tulsa, Oklahoma. Electronic address: skhalsa@laureateinstitute.org.
Ralph AdolphsCalifornia Institute of Technology, Pasadena, California.
Oliver G CameronDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Hugo D CritchleySackler Centre for Consciousness Science, University of Sussex, Brighton, United Kingdom.
Paul W DavenportDepartment of Physiology, University of Florida, Gainesville, Florida.
Justin S FeinsteinLaureate Institute for Brain Research, University of Tulsa, Tulsa, Oklahoma; Oxley College of Health Sciences, University of Tulsa, Tulsa, Oklahoma.
Jamie D FeusnerDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.
Sarah N GarfinkelSackler Centre for Consciousness Science, University of Sussex, Brighton, United Kingdom.
Richard D LaneDepartment of Psychiatry, University of Arizona, Tucson, Arizona.
Wolf E MehlingDepartment of Family and Community Medicine, University of California, San Francisco, San Francisco, California.
Alicia E MeuretDepartment of Psychology, Southern Methodist University, Dallas, Texas.
Charles B NemeroffDepartment of Psychiatry and Behavioral Sciences, University of Miami, Miami, Florida.
Stephen OppenheimerDepartment of Neurology, Johns Hopkins University, Baltimore, Maryland.
Frederike H PetzschnerTranslational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich, Zurich, Switzerland.
Olga PollatosDepartment of Clinical and Health Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.
Jamie L RhudyDepartment of Psychology, University of Tulsa, Tulsa, Oklahoma.
Lawrence P SchrammDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland; Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland.
W Kyle SimmonsLaureate Institute for Brain Research, University of Tulsa, Tulsa, Oklahoma; Oxley College of Health Sciences, University of Tulsa, Tulsa, Oklahoma.
Murray B SteinDepartment of Psychiatry, University of California, San Diego, San Diego, California.
Klaas E StephanTranslational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich, Zurich, Switzerland.
Omer Van den BerghDepartment of Health Psychology, University of Leuven, Leuven, Belgium.
Ilse Van DiestDepartment of Health Psychology, University of Leuven, Leuven, Belgium.
Andreas von LeupoldtDepartment of Health Psychology, University of Leuven, Leuven, Belgium.
Martin P PaulusLaureate Institute for Brain Research, University of Tulsa, Tulsa, Oklahoma.
Interoception Summit 2016 participants

Funding

ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Maëlle Camille Marie Gueguen · 2017 to 2026
$23.7M
NEUROBIOLOGY OF TRANSITION TO STIMULANT DEPENDENCER01DA016663 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAULUS, MARTIN P. · 2004 to 2010
$2.8M
Gender identity and own body perception implications for the neurobiology of gender dysphoriaR01HD087712 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE, SAVIC-BERGLUND, IVANKA · 2017 to 2020
$2.3M
Anxiety and reward interaction and prediction of outcomes in anorexia nervosaR01MH105662 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2015 to 2019
$2.3M
A wearable asthma trigger monitoring system with integrated physiological monitorU01EB021952 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI MEURET, ALICIA ESPERANZA, RAO, GOVIND · 2015 to 2015
$2.0M
Latent Constructs: Negative-Positive Valence Domains in Anxiety and DepressionR01MH101453 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAULUS, MARTIN P. · 2013 to 2016
$1.9M
Negative reinforcement and interoceptive dysfunction in stimulant dependence.R01DA027797 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAULUS, MARTIN P. · 2009 to 2013
$1.7M
STIMULANT DEPENDENCE: NEURAL MECHANISMS OF RELAPSER01DA018307 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAULUS, MARTIN P. · 2004 to 2008
$1.3M
Native American Pain Disparities: Exploring Nociceptive Processing DifferencesR01MD007807 · NIMHD · UNIVERSITY OF TULSA · PI RHUDY, JAMIE LYNN · 2013 to 2016
$1.2M
Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia NervosaK23MH112949 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB · 2017 to 2021
$994k
Approach-Avoidance Conflict-a multi-level predictor for exposure therapy responseK23MH108707 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI AUPPERLE, ROBIN L · 2016 to 2020
$976k
NIBIB NIH HHS U01 EB021952NICHD NIH HHS R01 HD087712NIDA NIH HHS R01 DA016663NIDA NIH HHS R01 DA018307NIDA NIH HHS R01 DA027797NIDA NIH HHS U01 DA041089NIGMS NIH HHS P20 GM121312NIMHD NIH HHS R01 MD007807NIMH NIH HHS K23 MH108707NIMH NIH HHS K23 MH112949NIMH NIH HHS R01 MH101453NIMH NIH HHS R01 MH105662NIMH NIH HHS R21 MH110865
6 · The paper itself

Abstract

Interoception refers to the process by which the nervous system senses, interprets, and integrates signals originating from within the body, providing a moment-by-moment mapping of the body's internal landscape across conscious and unconscious levels. Interoceptive signaling has been considered a component process of reflexes, urges, feelings, drives, adaptive responses, and cognitive and emotional experiences, highlighting its contributions to the maintenance of homeostatic functioning, body regulation, and survival. Dysfunction of interoception is increasingly recognized as an important component of different mental health conditions, including anxiety disorders, mood disorders, eating disorders, addictive disorders, and somatic symptom disorders. However, a number of conceptual and methodological challenges have made it difficult for interoceptive constructs to be broadly applied in mental health research and treatment settings. In November 2016, the Laureate Institute for Brain Research organized the first Interoception Summit, a gathering of interoception experts from around the world, with the goal of accelerating progress in understanding the role of interoception in mental health. The discussions at the meeting were organized around four themes: interoceptive assessment, interoceptive integration, interoceptive psychopathology, and the generation of a roadmap that could serve as a guide for future endeavors. This review article presents an overview of the emerging consensus generated by the meeting.

Indexed as

Mental HealthAwarenessBrainCognitionEmotionsHumansInteroceptionBiomarkerComputational psychiatryInteroceptionMental healthResearch Domain CriteriaTreatment

Identifiers

PMID29884281
PMCPMC6054486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.