Evidence map›Paper›PMID 29883738›Full record

ArticleThe ocular surface2018

A new scale for the assessment of conjunctival bulbar redness.

Ilaria Macchi, Vatinee Y Bunya, Mina Massaro-Giordano, Richard A Stone, Maureen G Maguire, Yuanjie Zheng, Min Chen, James Gee, Eli Smith, Ebenezer Daniel

Abstract read
In one paragraph

Article in The ocular surface, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Effect of vicryl 7 - 0 suturing versus diathermy closure on the ocular surface after small-gauge vitrectomy: a prospective randomized study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Grading Scales of Conjunctival Inflammation.Diagnostics (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Article
  6. An Investigation of Parturient Ocular Appearance in Sows.Animals : an open access journal from MDPI · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Grading reliability of the tear film viscosity examination.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Ilaria MacchiScheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA; Department of Ophthalmology, University Campus Biomedico, Rome, Italy.
Vatinee Y BunyaScheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.
Mina Massaro-GiordanoScheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.
Richard A StoneScheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.
Maureen G MaguireScheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.
Yuanjie ZhengScheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA; School of Information Science and Engineering, Shandong Normal University, China; Shandong Normal University, School of Information Science and Engineering, Key Lab of Intelligent Computing & Information Security in Universities of Shandong, Institute of Life Sciences, Shandong Provincial Key Laboratory for Distributed Computer Software Novel Technology, Key Lab of Intelligent Information Processing, Jinan, 250358, China.
Min ChenDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
James GeeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Eli SmithScheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.
Ebenezer DanielScheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: ebdaniel@pennmedicine.upenn.edu.
University of Pennsylvania · USPenn Presbyterian Medical Center · US

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Qi N Cui · 1985 to 2026
$19.5M
Developing new methods for early detection of Sjogren's syndromeR01EY026972 · NEI · UNIVERSITY OF PENNSYLVANIA · PI BUNYA, VATINEE Y · 2016 to 2020
$2.0M
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY026972
6 · The paper itself

Abstract

purposeCurrent scales for assessment of bulbar conjunctival redness have limitations for evaluating digital images. We developed a scale suited for evaluating digital images and compared it to the Validated Bulbar Redness (VBR) scale.

methodsFrom a digital image database of 4889 color corrected bulbar conjunctival images, we identified 20 images with varied degrees of redness. These images, ten each of nasal and temporal views, constitute the Digital Bulbar Redness (DBR) scale. The chromaticity of these images was assessed with an established image processing algorithm. Using 100 unique, randomly selected images from the database, three trained, non-physician graders applied the DBR scale and printed VBR scale. Agreement was assessed with weighted Kappa statistics (K

resultsThe DBR scale scores provide linear increments of 10 from 10-100 when redness is measured objectively with an established image processing algorithm. Exact agreement of all graders was 38% and agreement with no more than a difference of ten units between graders was 91%. K

conclusionThe novel DBR scale, with its objective linear chromatic steps, demonstrated improved reproducibility, fewer visualization artifacts and improved ease of use over the VBR scale for assessing conjunctival redness.

Indexed as

Diagnostic Techniques, OphthalmologicalConjunctivaConjunctivitisHumansImage Processing, Computer-AssistedReproducibility of ResultsSeverity of Illness IndexConjunctival rednessDigital image-based scale

Identifiers

PMID29883738
PMCPMC6574084
OpenAlexW2806441423

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.