Evidence map›Paper›PMID 29883736›Full record

ArticleNeuroImage2018

Solved problems for Granger causality in neuroscience: A response to Stokes and Purdon.

Lionel Barnett, Adam B Barrett, Anil K Seth

Abstract readComment
PubMed Publisher
In one paragraph

Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  7. Causal connectivity measures for pulse-output network reconstruction: Analysis and applications.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  14. Aberrant beta-band brain connectivity predicts speech motor planning deficits in post-stroke aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Lionel BarnettSackler Centre for Consciousness Science and Department of Informatics, University of Sussex, Brighton, BN1 9QJ, UK.
Adam B BarrettSackler Centre for Consciousness Science and Department of Informatics, University of Sussex, Brighton, BN1 9QJ, UK.
Anil K SethSackler Centre for Consciousness Science and Department of Informatics, University of Sussex, Brighton, BN1 9QJ, UK. Electronic address: a.k.seth@sussex.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Granger-Geweke causality (GGC) is a powerful and popular method for identifying directed functional ('causal') connectivity in neuroscience. In a recent paper, Stokes and Purdon (2017b) raise several concerns about its use. They make two primary claims: (1) that GGC estimates may be severely biased or of high variance, and (2) that GGC fails to reveal the full structural/causal mechanisms of a system. However, these claims rest, respectively, on an incomplete evaluation of the literature, and a misconception about what GGC can be said to measure. Here we explain how existing approaches resolve the first issue, and discuss the frequently-misunderstood distinction between functional and effective neural connectivity which underlies Stokes and Purdon's second claim.

Indexed as

NeurosciencesRestEffective connectivityFunctional connectivityGranger causalityStatistical inference

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.