Evidence map›Paper›PMID 29883715›Full record

ReviewProgress in retinal and eye research2018

Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors.

Frans Vinberg, Jeannie Chen, Vladimir J Kefalov

Open access · greenAbstract readReview
In one paragraph

Review in Progress in retinal and eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. T-type voltage-gated channels, NaCell communication and signaling : CCS · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Photoreceptor Ion Channels in Signaling and Disease.Advances in experimental medicine and biology · 2023
    Article
  16. Regulation of KInternational journal of molecular sciences · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Frans VinbergOphthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA; John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
Jeannie ChenZilkha Neurogenetic Institute, Department of Physiology and Neuroscience, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Vladimir J KefalovOphthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address: kefalov@wustl.edu.
University of Southern California · USUniversity of Utah · USWashington University in St. Louis · US

Funding

WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Philip Raymond Williams · 1985 to 2026
$18.4M
Phototransduction in health and diseaseR01EY012155 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jeannie Chen · 1998 to 2026
$11.8M
MECHANISMS OF ADAPTATION IN MAMMALIAN CONESR01EY019312 · NEI · WASHINGTON UNIVERSITY · PI KEFALOV, VLADIMIR JIVKOV · 2009 to 2017
$3.3M
Analyses of retinal circuits after rod rescue in a mouse model of human blindnessR01EY027193 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JEANNIE, FIELD, GREGORY DARIN · 2016 to 2020
$2.7M
PIGMENT DEPHOSPHORYLATION IN MAMMALIAN ROD AND CONE PHOTORECEPTORSR01EY025696 · NEI · WASHINGTON UNIVERSITY · PI KEFALOV, VLADIMIR JIVKOV · 2016 to 2019
$1.5M
CALCIUM HOMEOSTASIS IN MAMMALIAN ROD AND CONE PHOTORECEPTORSR01EY027387 · NEI · WASHINGTON UNIVERSITY · PI CHEN, JEANNIE, KEFALOV, VLADIMIR JIVKOV · 2017 to 2020
$1.4M
Assessment of Retinal Function in Health and Disease From Mouse To HumanR00EY026651 · NEI · UNIVERSITY OF UTAH · PI VINBERG, FRANS · 2017 to 2019
$722k
ASSESSMENT OF RETINAL FUNCTION IN HEALTH AND DISEASE FROM MOUSE TO HUMANK99EY026651 · NEI · WASHINGTON UNIVERSITY · PI VINBERG, FRANS · 2016 to 2017
$190k
NEI NIH HHS K99 EY026651NEI NIH HHS P30 EY002687NEI NIH HHS R00 EY026651NEI NIH HHS R01 EY012155NEI NIH HHS R01 EY019312NEI NIH HHS R01 EY025696NEI NIH HHS R01 EY027193NEI NIH HHS R01 EY027387
6 · The paper itself

Abstract

Calcium plays important roles in the function and survival of rod and cone photoreceptor cells. Rapid regulation of calcium in the outer segments of photoreceptors is required for the modulation of phototransduction that drives the termination of the flash response as well as light adaptation in rods and cones. On a slower time scale, maintaining proper calcium homeostasis is critical for the health and survival of photoreceptors. Decades of work have established that the level of calcium in the outer segments of rods and cones is regulated by a dynamic equilibrium between influx via the transduction cGMP-gated channels and extrusion via rod- and cone-specific Na

Indexed as

Adaptation, OcularCalciumHomeostasisHumansLight Signal TransductionRetinal Cone Photoreceptor CellsRetinal Rod Photoreceptor CellsCalciumCalciumLight adaptationNCKX1NCKX2NCKX4Photoreceptors

Identifiers

PMID29883715
PMCPMC6235702
OpenAlexW2805139026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.