ArticlePLoS genetics2018
Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
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- The Dyson equalizer: adaptive noise stabilization for low-rank signal detection and recovery.Information and inference : a journal of the IMA · 2025Article
- Principled PCA separates signal from noise in omics count data.bioRxiv : the preprint server for biology · 2025Article
- Memory CD4+ T cells sequentially restructure their 3D genome during stepwise activation.Frontiers in cell and developmental biology · 2025Article
- Unspecified asthma, childhood-onset, and adult-onset asthma have different causal genes: a Mendelian randomization analysis.Frontiers in immunology · 2024Article
- Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes.Cell reports · 2023Article
- Comorbidity genetic risk and pathways impact SARS-CoV-2 infection outcomes.Scientific reports · 2023Article
- Three-dimensional genome organization in immune cell fate and function.Nature reviews. Immunology · 2023Review
- Topologically associating domains are disrupted by evolutionary genome rearrangements forming species-specific enhancer connections in mice and humans.Cell reports · 2022Article
- Biwhitening Reveals the Rank of a Count Matrix.SIAM journal on mathematics of data science · 2022Article
- Article
- Pre-mitotic genome re-organisation bookends the B cell differentiation process.Nature communications · 2021Article
- Multi-level remodelling of chromatin underlying activation of human T cells.Scientific reports · 2021Article
- Cancer systems immunology.eLife · 2020Review
- Genome organization in immune cells: unique challenges.Nature reviews. Immunology · 2019Review
- Olfactory receptor genes make the case for inter-chromosomal interactions.Current opinion in genetics & development · 2019Review
- Fine mapping chromatin contacts in capture Hi-C data.BMC genomics · 2019Article
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been proposed that interactions between mammalian chromosomes, or transchromosomal interactions (also known as kissing chromosomes), regulate gene expression and cell fate determination. Here we aimed to identify novel transchromosomal interactions in immune cells by high-resolution genome-wide chromosome conformation capture. Although we readily identified stable interactions in cis, and also between centromeres and telomeres on different chromosomes, surprisingly we identified no gene regulatory transchromosomal interactions in either mouse or human cells, including previously described interactions. We suggest that advances in the chromosome conformation capture technique and the unbiased nature of this approach allow more reliable capture of interactions between chromosomes than previous methods. Overall our findings suggest that stable transchromosomal interactions that regulate gene expression are not present in mammalian immune cells and that lineage identity is governed by cis, not trans chromosomal interactions.
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Registered trials
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