ArticlePLoS biology2018
A sensory-motor neuron type mediates proprioceptive coordination of steering in C. elegans via two TRPC channels.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 74 citations in OpenAlex.
- Optimization of connectome weights for a neural network model generating both forward and backward locomotion in C. elegans.Scientific reports · 2026Article
- Short-term memory by distributed neural network oscillators in a simple nervous system.Current biology : CB · 2025Article
- Nicotine induces abnormal motor coupling through sensitization of a mechanosensory circuit in Caenorhabditis elegans.PLoS biology · 2025Article
- The roles of feedback loops in the Caenorhabditis elegans rhythmic forward locomotion.PLoS computational biology · 2025Article
- Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine-Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Unraveling anthelmintic targets and mechanisms of action of trans-cinnamaldehyde from cinnamon essential oil.Scientific reports · 2025Article
- PIEZO acts in an intestinal valve to regulate swallowing in C. elegans.Nature communications · 2024Article
- Article
- Neuronal sensorimotor integration guiding salt concentration navigation inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Can repetitive mechanical motion cause structural damage to axons?Frontiers in molecular neuroscience · 2024Review
- Brain-wide representations of behavior spanning multiple timescales and states in C. elegans.Cell · 2023Article
- A proprioceptive feedback circuit drivesProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Modelling learning in Caenorhabditis elegans chemosensory and locomotive circuitry for T-maze navigation.The European journal of neuroscience · 2022Article
- A somatic proteoglycan controls Notch-directed germ cell fate.Nature communications · 2021Article
- A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior.eLife · 2021Article
- Phase response analyses support a relaxation oscillator model of locomotor rhythm generation ineLife · 2021Article
- An asymmetric mechanical code ciphers curvature-dependent proprioceptor activity.Science advances · 2021Article
- Proprioception, the regulator of motor function.BMB reports · 2021Review
- The Prop1-like homeobox geneeLife · 2021Article
- Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Animal locomotion is mediated by a sensory system referred to as proprioception. Defects in the proprioceptive coordination of locomotion result in uncontrolled and inefficient movements. However, the molecular mechanisms underlying proprioception are not fully understood. Here, we identify two transient receptor potential cation (TRPC) channels, trp-1 and trp-2, as necessary and sufficient for proprioceptive responses in C. elegans head steering locomotion. Both channels are expressed in the SMDD neurons, which are required and sufficient for head bending, and mediate coordinated head steering by sensing mechanical stretches due to the contraction of head muscle and orchestrating dorsal head muscle contractions. Moreover, the SMDD neurons play dual roles to sense muscle stretch as well as to control muscle contractions. These results demonstrate that distinct locomotion patterns require dynamic and homeostatic modulation of feedback signals between neurons and muscles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.