ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Clinical Significance of Serological and Urological Levels of Bladder Cancer-Specific Antigen-1 (BLCA-1) in Bladder Cancer.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Biomarkers for Recurrence and Prognosis in Metastatic Urothelial Cancer: Emerging Clinical Applications.Journal of Cancer · 2026Review
- Plasma aromatase as a sensitive and selective potential biomarker of bladder cancer and its role in tumorigenesis.Oncology letters · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND The aim of this study was to determine the clinical significance of the expression levels of bladder cancer-specific antigen-1 (BLCA-1) in the diagnosis of bladder cancer (BC). The study also determined the relationship between BLCA-1 expression levels and the clinical manifestation of BC. MATERIAL AND METHODS Patient samples were derived from 66 cases of BC that presented at the Department of Urology, Affiliated Hospital of Chengde Medical University, were recruited from April 2014 to May 2015, and 64 healthy control cases. Serum and urine BLCA-1 levels were detected by enzyme-linked immunosorbent assay (ELISA). RESULTS Urine BLCA-1 levels in BC patients were significantly higher than that found in healthy controls (P<0.01). BLCA-1 levels in the urine of patients without mucus membrane invasion (Ta) were significantly different from urine levels found in patients with mucus membrane invasion (T1-T4; P=0.022). BLCA-1 levels in the serum of patients without muscular coat invasion (Ta-T1) were significantly different than serum levels of patients with muscular coat invasion (T2-T4; P=0.042). CONCLUSIONS BLCA-1 is involved in the appearance and development of BC. Clinical detection of serum and urine BLCA-1 protein levels showed a high level of sensitivity and specificity in diagnosing BC. Further study of the functional expression of BLCA-1 levels as a valuable and novel diagnostic marker in BC is clearly warranted.
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